Evidence map›Paper›PMID 21128770›Full record

ReviewArchives of pathology & laboratory medicine2010

Molecular pathogenesis of sporadic melanoma and melanoma-initiating cells.

Yunyi Kong, Suresh M Kumar, Xiaowei Xu

Open access · greenAbstract readReview
In one paragraph

Review in Archives of pathology & laboratory medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Molecular genetic and immunotherapeutic targets in metastatic melanoma.Virchows Archiv : an international journal of pathology · 2017
    Review
  5. Mutations in CoagulationTH open : companion journal to thrombosis and haemostasis · 2017
    Article
  6. Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.Laboratory investigation; a journal of technical methods and pathology · 2017
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Molecular bases of cutaneous and uveal melanomas.Pathology research international · 2011
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yunyi KongDepartment of Pathology, Cancer Hospital, Fudan University, Shanghai, People’s Republic of China.
Suresh M Kumar
Xiaowei Xu
Fudan University Shanghai Cancer Center · CN

Funding

Tissue &PathologyP50CA093372 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2001 to 2009
$15.4M
Characterization of neural crest stem cells in human hair follicles.R01AR054593 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI XU, XIAOWEI · 2009 to 2013
$1.9M
Ultrasensitive FACTT assays for serum biomarkersR21CA116103 · NCI · UNIVERSITY OF PENNSYLVANIA · PI XU, XIAOWEI · 2007 to 2008
$389k
NCI NIH HHS CA-093372NCI NIH HHS CA-116103NCI NIH HHS P50 CA093372NCI NIH HHS R21 CA116103NIAMS NIH HHS R01 AR054593
6 · The paper itself

Abstract

Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of melanoma-initiating cells during melanomagenesis and progression will also be discussed. Understanding pathogenesis of melanoma may uncover new diagnostic clues and therapeutic targets for this increasingly prevalent disease.

Indexed as

Gene Expression Regulation, NeoplasticApoptosisCell ProliferationHumansMelanocytesMelanomaNeoplastic Stem CellsPrognosisSkin Neoplasms

Identifiers

PMID21128770
PMCPMC4049155
OpenAlexW2182881604

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.