Evidence map›Paper›PMID 21128753›Full record

ReviewExpert review of respiratory medicine2010

The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition.

Joseph E Levitt, Michael A Matthay

Abstract readReview
In one paragraph

Review in Expert review of respiratory medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Molecular mechanism of miRNA-23a in sepsis-induced lung injury.American journal of translational research · 2023
    Article
  3. Article
  4. miR-942-5p prevents sepsis-induced acute lung injury via targeting TRIM37.International journal of experimental pathology · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph E LevittDivision of Pulmonary/Critical Care, Stanford University, 300 Pasteur Drive, MC 5236 Stanford, CA 94305, USA. jlevitt@stanford.edu
Michael A Matthay

Funding

Early Acute Lung Injury: Prospective Evaluation Prior to Respiratory FailureK23HL091334 · NHLBI · STANFORD UNIVERSITY · PI LEVITT, JOSEPH ERIC · 2009 to 2013
$671k
NHLBI NIH HHS 1K23HL091334-01A2NHLBI NIH HHS K23 HL091334NHLBI NIH HHS K23HL091334-01A2
6 · The paper itself

Abstract

Despite significant advances in our understanding of the pathophysiology of acute lung injury, a lung-protective strategy of mechanical ventilation remains the only therapy with a proven survival advantage. Numerous pharmacologic therapies have failed to show benefit in multicenter clinical trials. The paradigm of early, goal-directed therapy of sepsis suggests greater clinical benefit may derive from initiating therapy prior to the onset of respiratory failure that requires mechanical ventilation. Thus, there is heightened interest in more accurate and complete characterization of high-risk patient populations and identification of patients in the early stage of acute lung injury, prior to the need for mechanical ventilation. This article discusses the growing literature on clinical predictors of acute lung injury (including risk factors for specific subgroups) with an emphasis on transfusion-related risk factors and recent research targeting the early identification of high-risk patients and those with early acute lung injury prior to the onset of respiratory failure.

Indexed as

Acute Lung InjuryBiomarkersDisease ProgressionEarly DiagnosisEvidence-Based MedicineHumansOdds RatioPredictive Value of TestsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeBiomarkers

Identifiers

PMID21128753
PMCPMC3044497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.