Evidence map›Paper›PMID 21128721›Full record

ReviewNanomedicine (London, England)2010

Engineering nanomedicines for improved melanoma therapy: progress and promises.

Di Bei, Jianing Meng, Bi-Botti C Youan

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 97 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Cubic liquid crystalline nanoparticles containing a polysaccharideSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Di BeiLaboratory of Future Nanomedicines & Theoretical Chronopharmaceutics, Division of Pharmaceutical Science, School of Pharmacy, University of Missouri-Kansas City, MO 64110, USA.
Jianing Meng
Bi-Botti C Youan
University of Missouri–Kansas City · US

Funding

Microbicide Loaded Nanocarriers for Topical Delivery in HIV/AIDS PreventionR21AI083092 · NIAID · UNIVERSITY OF MISSOURI KANSAS CITY · PI YOUAN, BI-BOTTI CELESTIN · 2009 to 2010
$371k
Heparin Containing Microparticles for Pulmonary DeliveryR15GM069397 · NIGMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI YOUAN, BI-BOTTI CELESTIN · 2005 to 2007
$213k
NIAID NIH HHS R21 AI083092NIAID NIH HHS R21AI083092NIGMS NIH HHS R15 GM069397
6 · The paper itself

Abstract

Once metastatic, melanoma remains one of the most aggressive and morbid malignancies. Moreover, in past decades, the overall survival for advanced unresectable melanoma exhibited a constancy of poor prognosis. Low response rates and serious adverse effects have been characteristic of standard therapy based on a combination of chemotherapeutic agents or immunotherapy with IL-2. For example, the chemotherapy including dacarbazine, carmustin, cisplatin and tamoxifen is known as 'Dartmouth regimen' while the CVD regimen comprises carmustine, vinblastine and dacarbazine. Thus, there is an urgent and critical need to reformulate these bioactive agents using nanoscience and nanotechnology as alternative strategies. This article overviews current design and evaluation of nanomedicine undertaken to address this unmet medical need. The nanomedicines studied include polymeric nanoparticles, liposomes, polymersomes, dendrimers, cubosomes, niosomes and nanodiamonds. In this preclinical article, nanotechnology provides hope for effective treatment of this aggressive and largely treatment-resistant disease.

Indexed as

Antineoplastic AgentsCarmustineCisplatinDacarbazineDrug Delivery SystemsHumansMelanomaNanomedicineTamoxifenAntineoplastic AgentsCarmustineCisplatinDacarbazineTamoxifen

Identifiers

PMID21128721
PMCPMC3685319
OpenAlexW2149566258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.