Evidence map›Paper›PMID 21128716›Full record

ArticleNanomedicine (London, England)2010

Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration.

Hui Dai, Raghavendra S Navath, Bindu Balakrishnan, Bharath Raja Guru, Manoj K Mishra, Roberto Romero, Rangaramanujam M Kannan, Sujatha Kannan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

  1. Intrathecal drug delivery in the era of nanomedicine.Advanced drug delivery reviews · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hui DaiDepartment of Pediatrics (Critical Care Medicine), Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA.
Raghavendra S Navath
Bindu Balakrishnan
Bharath Raja Guru
Manoj K Mishra
Roberto Romero
Rangaramanujam M Kannan
Sujatha Kannan
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health · USWayne State University · US

Funding

The Role Of Subclinical Infection And Cytokines In Preterm ParturitionZIAHD002400 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROMERO, ROBERTO · 2009 to 2025
$254.4M
Imaging and therapy of intrauterine inflammation induced perinatal brain injuryK08HD050652 · NICHD · WAYNE STATE UNIVERSITY · PI KANNAN, SUJATHA · 2007 to 2010
$510k
NICHD NIH HHS 1K08HD050652NICHD NIH HHS K08 HD050652NICHD NIH HHS N01 HD023342
6 · The paper itself

Abstract

aimUnderstanding the interactions between nanomaterials and disease processes is crucial for designing effective therapeutic approaches. This article explores the unusual neuroinflammation targeting of dendrimers (with no targeting ligands) in the brain, with significant consequences for nanoscale materials in medicine.

methodThe in vivo biodistribution of fluorescent-labeled neutral generation-4- polyamidoamine dendrimers (∼4 nm) in a rabbit model of cerebral palsy was explored following subarachnoid administration.

resultsThese dendrimers, with no targeting ligands, were localizing in activated microglia and astrocytes (cells responsible for neuroinflammation), even in regions far moved from the site of injection, in newborn rabbits with maternal inflammation-induced cerebral palsy.

conclusionThis intrinsic ability of dendrimers to localize inactivated microglia and astrocytes can enable targeted delivery of therapeutics in disorders such as cerebral palsy, Alzheimer's and multiple sclerosis.

Indexed as

AnimalsAnimals, NewbornAstrocytesBrainCerebral PalsyChromatography, High Pressure LiquidDendrimersFemaleFluorescein-5-isothiocyanateMaleMicrogliaRabbitsSubarachnoid SpaceDendrimersFluorescein-5-isothiocyanatePAMAM Starburst

Identifiers

PMID21128716
PMCPMC3095441
OpenAlexW2085147347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.