ArticleWorld journal of gastroenterology2010
Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Protective effect of melatonin against age-related ischemia-reperfusion injury is associated with the NLRP3 inflammasome pathway.Journal of physiology and biochemistry · 2026Article
- Steatotic Donor Transplant Livers: Preservation Strategies to Mitigate against Ischaemia-Reperfusion Injury.International journal of molecular sciences · 2024Review
- How to Preserve Steatotic Liver Grafts for Transplantation.Journal of clinical medicine · 2023Review
- The pathophysiological mechanism between hypopituitarism and nonalcoholic fatty liver disease.iLIVER · 2022Review
- Pharmacological Benefits and Risk of Using Hormones in Organ Perfusion and Preservation Solutions in the Aspect of Minimizing Hepatic Ischemia-Reperfusion Injury during Storage.BioMed research international · 2019Review
- Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1World journal of gastroenterology · 2017Article
- Melatonin role preventing steatohepatitis and improving liver transplantation results.Cellular and molecular life sciences : CMLS · 2016Review
- Effects of Institut Georges Lopez-1 and Celsior preservation solutions on liver graft injury.World journal of gastroenterology · 2015Article
- Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach.World journal of gastroenterology · 2015Article
- Emerging concepts in liver graft preservation.World journal of gastroenterology · 2015Review
- Article
- Polyethylene glycol rinse solution: an effective way to prevent ischemia-reperfusion injury.World journal of gastroenterology · 2014Article
- How to protect liver graft with nitric oxide.World journal of gastroenterology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury.
methodsSteatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused "ex vivo" for 2 h at 37degrees C. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.
resultsSteatotic livers preserved in IGL-1 solution supplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1 solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.
conclusionIGL-1 enrichment with IGF-1 increased fatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion.
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