ArticleNeuroradiology2011
Axial diffusivity is increased in the degenerating superior cerebellar peduncles of Friedreich's ataxia.
Article in Neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Oculomotor and Vestibular Deficits in Friedreich Ataxia - Systematic Review and Meta-Analysis of Quantitative Measurements.Cerebellum (London, England) · 2024Pooled it
- Training-induced improvements in postural control are accompanied by alterations in cerebellar white matter in brain injured patients.NeuroImage. Clinical · 2015Trial
- White matter changes in patients with friedreich ataxia after treatment with erythropoietin.Journal of neuroimaging : official journal of the American Society of NeuroimagingTrial
- Late-onset GM2 gangliosidosis: magnetic resonance imaging, diffusion tensor imaging, and correlational fiber tractography differentiate Tay-Sachs and Sandhoff diseases.Journal of neurology · 2025Article
- Chronic Cocaine Use and White Matter Coherence: A Diffusion Tensor Imaging Study.Journal of studies on alcohol and drugs · 2023Article
- Reduced cerebello-cerebral functional connectivity correlates with disease severity and impaired white matter integrity in Friedreich ataxia.Journal of neurology · 2023Article
- Associations between N-Acetylaspartate and white matter integrity in individuals with schizophrenia and unaffected relatives.Psychiatry research. Neuroimaging · 2023Article
- Brain MRI detects early-stage alterations and disease progression in Friedreich ataxia.Brain communications · 2023Article
- Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness.European archives of psychiatry and clinical neuroscience · 2022Article
- Utility of Diffusion and Magnetization Transfer MRI in Cervical Spondylotic Myelopathy: A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- Abnormal brain functional and structural connectivity between the left supplementary motor area and inferior frontal gyrus in moyamoya disease.BMC neurology · 2022Article
- The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Corrigendum: Assessment of cerebral and cerebellar white matter microstructure in spinocerebellar ataxias 1, 2, 3, and 6 using diffusion MRI.Frontiers in neurology · 2022Article
- Longitudinal structural brain changes in Friedreich ataxia depend on disease severity: the IMAGE-FRDA study.Journal of neurology · 2021Article
- Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging.Fluids and barriers of the CNS · 2021Article
- Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington's Disease.Frontiers in neuroscience · 2021Article
- White matter microstructure in women with acute and remitted anorexia nervosa: an exploratory neuroimaging study.Brain imaging and behavior · 2020Article
- MR Neurography: Normative Values in Correlation to Demographic Determinants in Children and Adolescents.Clinical neuroradiology · 2020Article
- Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE-FRDA study.Human brain mapping · 2020Article
- Effects of unilateral cortical resection of the visual cortex on bilateral human white matter.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDecreased fractional anisotropy (FA) demonstrated by diffusion tensor MR imaging (DTI) in areas of white matter (WM) damage is generally associated with increase of radial diffusivity, while axial diffusivity is reported to be decreased, unchanged, or increased. Aiming to better define the type of axial diffusivity change occurring in a typical human neurodegenerative disease, we investigated axial and radial diffusivity in Friedreich's ataxia (FRDA) which is characterized by selective neuronal loss of the dentate nuclei and atrophy and decreased FA of the superior cerebellar peduncles (SCPs).
methodsAxial and radial diffusivity of the whole-brain WM were evaluated in 14 patients with FRDA and 14 healthy volunteers using DTI at 1.5 T and the tract-based spatial statistics (TBSS) method, part of FSL software.
resultsTBSS analysis showed a single area in the central midbrain corresponding to the decussation of the SCPs which exhibited lower FA in patients than in controls. In this area, a significant increase of both axial and radial diffusivity was observed. No clusters of significantly decreased axial diffusivity were observed, while additional clusters of increase of radial diffusivity were present throughout the brain.
conclusionsThe selective decrease of FA in SCPs of FRDA patients reflecting chronic WM tract damage is associated with increase of both the axial and radial diffusivity, the latter more pronounced than the former. The ultrastructural and biophysical bases of the increased axial diffusivity in chronically degenerating WM tracts deserve further studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.