ReviewCurrent pain and headache reports2011
The hypothalamus: specific or nonspecific role in the pathophysiology of trigeminal autonomic cephalalgias?
Review in Current pain and headache reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of trigeminal microvascular decompression in the treatment of SUNCT and SUNA.Current pain and headache reports · 2013Pooled it
- Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache.The journal of headache and pain · 2024Review
- A Hypothalamic-Controlled Neural Reflex Promotes Corneal Inflammation.Investigative ophthalmology & visual science · 2021Article
- Caffeine and Primary (Migraine) Headaches-Friend or Foe?Frontiers in neurology · 2019Review
- Coexistence of contralateral cluster headache and probable paroxysmal hemicrania: a case report.SpringerPlus · 2016Article
- Cortical plasticity in episodic and chronic cluster headache.NeuroImage. Clinical · 2014Article
- Bilateral descending hypothalamic projections to the spinal trigeminal nucleus caudalis in rats.PloS one · 2013Article
- Trigeminal autonomic cephalgias.British journal of pain · 2012Article
- Trigeminal autonomic cephalalgias: A review of recent diagnostic, therapeutic and pathophysiological developments.Annals of Indian Academy of Neurology · 2012Article
- Alcohol-induced headaches: Evidence for a central mechanism?Journal of neurosciences in rural practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical features of trigeminal autonomic cephalalgias (TACs), such as trigeminal distribution of pain, circadian/circannual rhythmicity, and ipsilateral cranial autonomic features, suggest a crucial role of the hypothalamus in the underlying pathophysiology of these primary headache disorders. Hypothalamic involvement is supported by several neuroimaging, neuroendocrine, genetic, experimental pain, and animal studies. Unfortunately, these different studies were unable to resolve the paramount question of whether the detected hypothalamic alterations are pathognomonic for TACs or whether they merely represent an epiphenomenon of different pain conditions in general. This review summarizes studies on hypothalamic involvement in TAC pathophysiology, demonstrates hypothalamic activation in other painful diseases, and evaluates the role of the hypothalamus in the pathophysiologic mechanisms associated with these different conditions.
Indexed as
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21128020What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.