ArticleImmunologic research2011
Receptor signaling in immune cell development and function.
Article in Immunologic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Aromatic Amino Acid Metabolites: Molecular Messengers Bridging Immune-Microbiota Communication.Immune network · 2025Review
- Molecular and therapeutic effect of CRISPR in treating cancer.Medical oncology (Northwood, London, England) · 2023Review
- Delayed diagnosis of myelitis in a patient with Vogt-Koyanagi-Harada disease: a case report.The Journal of international medical research · 2021Article
- BAFF inhibits autophagy promoting cell proliferation and survival by activating CaCellular signalling · 2019Article
- Article
- mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium.Scientific reports · 2016Article
- Diacylglycerol Kinases in T Cell Tolerance and Effector Function.Frontiers in cell and developmental biology · 2016Review
- Article
- Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Role of diacylglycerol kinases in T cell development and function.Critical reviews in immunology · 2013Review
- Article
- T cell Receptor Signal Transduction in T lymphocytes.Journal of clinical & cellular immunology · 2012Article
- Tumor suppressor TSC1 is critical for T-cell anergy.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Differential requirement of RasGRP1 for γδ T cell development and activation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role and regulation of mTOR in T-lymphocyte function.Archivum immunologiae et therapiae experimentalis · 2012Review
- The role of tuberous sclerosis complex 1 in regulating innate immunity.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
- Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Regulation of T-cell survival and mitochondrial homeostasis by TSC1.European journal of immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE transduces signal that promotes mast cell survival and induces mast cell activation. In dendritic cells and macrophages, the toll-like receptors recognize microbial pathogens and play critical roles for both innate and adaptive immunity against pathogens. Our research explores how signaling from these receptors is transduced and regulated to better understand these immune cells. Our recent studies have revealed diacylglycerol kinases and TSC1/2-mTOR as critical signaling molecules/regulators in T cells, mast cells, dendritic cells, and macrophages.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.