ArticleEuropean journal of nutrition2011
Integrity of erythrocytes of hypercholesterolemic and normocholesterolemic rats during ingestion of different structured lipids.
Article in European journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Dietary milk fat globule membrane supplementation combined with regular exercise improves skeletal muscle strength in healthy adults: a randomized double-blind, placebo-controlled, crossover trial.Nutrition journal · 2015Trial
- In vivo influence of extract from Aronia melanocarpa on the erythrocyte membranes in patients with hypercholesterolemia.Medical science monitor : international medical journal of experimental and clinical research · 2012Trial
- Structured Lipids Engineering for Health: Novel Formulations Enriched inMetabolites · 2023Review
- Effects of a novel medium-long-medium-type structured lipid synthesized using a two-step enzymatic method on lipid metabolism and obesity protection in experimental mice.Food science & nutrition · 2023Article
- The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection.Malaria journal · 2019Article
- Antioxidant Effects ofOxidative medicine and cellular longevity · 2019Article
- Increased erythrocytic osmotic fragility in anemic domestic shorthair and purebred cats.Journal of feline medicine and surgery · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the effect of medium-chain fatty acid (MCFA)-rich mustard oil and polyunsaturated fatty acid (PUFA)-rich mustard oil on erythrocyte membrane composition and osmotic fragility in normal and hypercholesterolemic rats.
methodMembrane composition was analyzed using standard kits. Osmotic fragility was determined using method described by Dacie and Lewis. Fatty acid composition of membrane was analyzed using gas chromatographic methods. Membrane shape analysis was performed using scanning electron microscope.
resultsOsmotic fragility data suggested that the erythrocyte membrane of hypercholesterolemic rats were relatively more fragile than that of the normal rat's membrane, which could be reversed with the addition of MCFA- and PUFA-rich oil in the diet. The increased plasma cholesterol in hypercholesterolemic rats could also be lowered by the experimental oils. There was also marked changes in the fatty acid composition of the plasma and erythrocyte membrane phospholipids. Polyunsaturated fatty acids decreased in the plasma of the hypercholesterolemic subjects were increased with the treatment of the experimental oils. Shape changes of the membrane holes were observed in the hypercholesterolemic condition, which was brought to normal shape with the administration of the experimental oils.
conclusionIn conclusion, rat erythrocytes appear to be deformed and became more fragile in cholesterol-rich blood. This deformity and fragility was partially reversed by experimental oils by virtue of their ability to lower the extent of hypercholesterolemia.
Indexed as
Identifiers
21127890What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.