ArticleProceedings of the National Academy of Sciences of the United States of America2010
Old gene duplication facilitates origin and diversification of an innovative communication system--twice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- The probability of genetic parallelism and convergence in natural populations.Proceedings. Biological sciences · 2012Pooled it
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- Evolutionary trajectories of teleost olfactory signaling genes shaped by long-term redundancy after whole-genome duplication.iScience · 2026Article
- Gene expression correlates and mechanistic insights into electric organ discharge duration changes in mormyrid electric fish.The Journal of experimental biology · 2025Article
- Organization of the stalk system on electrocytes in mormyrid weakly electric fish Campylomormyrus compressirostris.Cell and tissue research · 2025Article
- Zebrafish: unraveling genetic complexity through duplicated genes.Development genes and evolution · 2024Review
- CAM evolution is associated with gene family expansion in an explosive bromeliad radiation.The Plant cell · 2024Article
- Differential expression of steroid-related genes across electrosensory brain regions in two sexually dimorphic species of electric knifefish.General and comparative endocrinology · 2024Review
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- Ecologically mediated differences in electric organ discharge drive evolution in a sodium channel gene in South American electric fishes.Biology letters · 2024Article
- Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.Molecular and cellular endocrinology · 2023Article
- Molecular evolution of the ependymin-related gene epdl2 in African weakly electric fish.G3 (Bethesda, Md.) · 2023Article
- Evolution of central neural circuits: state of the art and perspectives.Nature reviews. Neuroscience · 2022Review
- Divergent cis-regulatory evolution underlies the convergent loss of sodium channel expression in electric fish.Science advances · 2022Article
- Review
- Advancing human disease research with fish evolutionary mutant models.Trends in genetics : TIG · 2022Review
- De Novo Genome Assembly of the Electric Fish Brachyhypopomus occidentalis (Hypopomidae, Gymnotiformes).Genome biology and evolution · 2021Article
- Recent genome duplications facilitate the phenotypic diversity of Hb repertoire in the Cyprinidae.Science China. Life sciences · 2021Article
- Morphological diversity of acoustic and electric communication systems of mochokid catfish.The Journal of comparative neurology · 2021Article
- Genomic Evidence for Convergent Molecular Adaptation in Electric Fishes.Genome biology and evolution · 2021Article
8 more citing papers are in PubMed but not listed here.
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4 authors at 3 institutions in 2 countries.
Funding
Abstract
The genetic basis of parallel innovation remains poorly understood due to the rarity of independent origins of the same complex trait among model organisms. We focus on two groups of teleost fishes that independently gained myogenic electric organs underlying electrical communication. Earlier work suggested that a voltage-gated sodium channel gene (Scn4aa), which arose by whole-genome duplication, was neofunctionalized for expression in electric organ and subsequently experienced strong positive selection. However, it was not possible to determine if these changes were temporally linked to the independent origins of myogenic electric organs in both lineages. Here, we test predictions of such a relationship. We show that Scn4aa co-option and rapid sequence evolution were tightly coupled to the two origins of electric organ, providing strong evidence that Scn4aa contributed to parallel innovations underlying the evolutionary diversification of each electric fish group. Independent evolution of electric organs and Scn4aa co-option occurred more than 100 million years following the origin of Scn4aa by duplication. During subsequent diversification of the electrical communication channels, amino acid substitutions in both groups occurred in the same regions of the sodium channel that likely contribute to electric signal variation. Thus, the phenotypic similarities between independent electric fish groups are also associated with striking parallelism at genetic and molecular levels. Our results show that gene duplication can contribute to remarkably similar innovations in repeatable ways even after long waiting periods between gene duplication and the origins of novelty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.