ReviewJournal of applied physiology (Bethesda, Md. : 1985)2011
Emergence of airway smooth muscle functions related to structural malleability.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Membrane adhesion junctions regulate airway smooth muscle phenotype and function.Physiological reviews · 2023Review
- Effects of airway tree asymmetry on the emergence and spatial persistence of ventilation defects.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Modelling airway smooth muscle passive length adaptation via thick filament length distributions.Journal of theoretical biology · 2013Article
- Airway smooth muscle in the pathophysiology and treatment of asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Review
- Structural analysis of smooth muscle tropomyosin α and β isoforms.The Journal of biological chemistry · 2012Article
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2 authors.
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Abstract
The function of a complex system such as a smooth muscle cell is the result of the active interaction among molecules and molecular aggregates. Emergent macroscopic manifestations of these molecular interactions, such as the length-force relationship and its associated length adaptation, are well documented, but the molecular constituents and organization that give rise to these emergent muscle behaviors remain largely unknown. In this minireview, we describe emergent properties of airway smooth muscle that seem to have originated from inherent fragility of the cellular structures, which has been increasingly recognized as a unique and important smooth muscle attribute. We also describe molecular interactions (based on direct and indirect evidence) that may confer malleability on fragile structural elements that in turn may allow the muscle to adapt to large and frequent changes in cell dimensions. Understanding how smooth muscle works may hinge on how well we can relate molecular events to its emergent macroscopic functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.