ArticleJournal of the American Society of Nephrology : JASN2011
Refined mapping of the renal failure RF-3 quantitative trait locus.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3.Journal of hypertension · 2017Article
- Refined mapping of a hypertension susceptibility locus on rat chromosome 12.Hypertension (Dallas, Tex. : 1979) · 2014Article
- SORCS1 contributes to the development of renal disease in rats and humans.Physiological genomics · 2013Article
- A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability.Journal of the American Society of Nephrology : JASN · 2012Article
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Authors and funding
5 authors.
Funding
Abstract
Rf-3, a quantitative trait locus (QTL) on rat chromosome 3, affects the development of CKD in Fawn-Hooded Hypertensive (FHH) rats. This QTL spans 110 Mb and approximately 1400 genes; therefore, narrowing the position of this locus is necessary to elucidate potential candidate genes. Here, we used congenic models and comparative genomics to refine the Rf-3 candidate region. We generated congenic lines carrying smaller intervals (subcongenics) of the Rf-3 region and used these lines to reduce the Rf-3 candidate region by 94% (to 7.1 Mb). We used comparative genomics to identify QTL for both nephropathy and albuminuria in the syntenic region of this interval for both human and mouse. We also used the overlapping homologous regions to reduce the number of likely positional candidate genes to 13 known or predicted genes. By combining congenic models and cross-species studies, we narrowed the list of candidate genes to a level that we could sequence the whole interval to further identify the causative gene in future studies.
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