ArticleJournal of cardiothoracic and vascular anesthesia2011
Vasopressin deficiency and vasodilatory state in end-stage liver disease.
Article in Journal of cardiothoracic and vascular anesthesia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
- Post-reperfusion syndrome in liver transplant recipients: What is new in prevention and management?World journal of critical care medicine · 2025Review
- Vasopressin Is Not Associated With Severe Kidney Injury in Liver Transplantation: A Propensity Score-adjusted Analysis.Transplantation direct · 2025Article
- Vasoplegic Syndrome and Anaesthesia: A Narrative Review.Turkish journal of anaesthesiology and reanimation · 2023Article
- Prophylactic consequences of sodium salicylate nanoparticles in cisplatin-mediated hepatotoxicity.Scientific reports · 2023Article
- The Use of Methylene Blue during Liver Transplantation for Vasoplegia.Case reports in anesthesiology · 2021Article
- Anaesthesia for Liver Transplantation: An Update.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2020Article
- High-dose hydroxocobalamin in end-stage liver disease and liver transplantation.Drugs & therapy perspectives : for rational drug selection and use · 2019Article
- Visual quality assessment of the liver graft by the transplanting surgeon predicts postreperfusion syndrome after liver transplantation: a retrospective cohort study.BMC anesthesiology · 2018Article
- Performance measurement of intraoperative systolic arterial pressure to predict in-hospital mortality in adult liver transplantation.Scientific reports · 2017Article
- Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort.World journal of hepatology · 2017Article
- Postreperfusion syndrome during liver transplantation.Korean journal of anesthesiology · 2015Review
- Hepatosplanchnic circulation in cirrhosis and sepsis.World journal of gastroenterology · 2015Review
- Current clinical management of pulmonary arterial hypertension.Circulation research · 2014Review
- Liver transplantation: Advances and perioperative care.Indian journal of anaesthesia · 2012Article
- Bench-to-bedside review: Vasopressin in the management of septic shock.Critical care (London, England) · 2011Review
- Strategies to avoid empiric blood product administration in liver transplant surgery.Saudi journal of anaesthesiaReview
- Intraoperative cardiac complications in liver transplantation: A comprehensive review of management strategies.Saudi journal of anaesthesiaReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesRelative vasopressin deficiency, a contributor to vasodilatory septic shock, also may be a cause of the vasodilatory state in liver disease. This study assessed endogenous vasopressin levels in patients with liver disease and their hemodynamic response to exogenous vasopressin.
designA prospective, observational study.
settingA single-center, tertiary hospital.
participantsHuman subjects undergoing liver transplantation or major surgery.
interventionsVasopressin levels were measured in 28 patients with liver disease undergoing liver transplantation and 7 control patients with normal liver function. Additionally, intravenous vasopressin was administered to 20 liver transplant recipients, and the hemodynamic response was observed. MEASUREMENTS AND MAIN
resultsPatients with liver disease had significantly lower baseline vasopressin levels than controls (19.3 ± 27.1 pg/mL v 50.9 ± 36.7 pg/mL, p = 0.015). Patients with low vasopressin levels (≤20 pg/mL) were more likely to have lower baseline mean blood pressure (≤80 mmHg) than patients with high vasopressin levels (11/16 v 0/4, p = 0.013). Systemic vascular resistance increased by 33% 3 minutes after intravenous vasopressin. Thirteen of 16 patients with low vasopressin levels compared with 1 of 4 patients with high vasopressin levels responded to exogenous vasopressin, with an increase of mean blood pressure by more than 20% (p = 0.028).
conclusionsPatients with liver disease have lower vasopressin levels than controls and respond with a brisk vasoconstrictor response to exogenous vasopressin. Therefore, relative endogenous vasopressin deficiency may contribute to vasodilatory shock in liver disease similar to what has been observed in septic shock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.