ArticleBMC cancer2010
Specific genomic aberrations in primary colorectal cancer are associated with liver metastases.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Prospective validation in epithelial tumors of a gene expression predictor of liver metastasis derived from uveal melanoma.Scientific reports · 2019Pooled it
- Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis.PloS one · 2016Pooled it
- Multimodal radiomics for precision management of colorectal cancer.Discover oncology · 2026Review
- Cytogenetic signatures favoring metastatic organotropism in colorectal cancer.Nature communications · 2025Article
- D-dimer to lymphocyte ratio can serve as a potential predictive and prognostic value in colorectal cancer patients with liver metastases.BMC surgery · 2023Article
- Association of genomic profiles and survival in early onset and screening-age colorectal cancer patients with liver metastases resected over 15 years.Journal of surgical oncology · 2022Article
- Brusatol Inhibits Proliferation and Metastasis of Colorectal Cancer by Targeting and Reversing the RhoA/ROCK1 Pathway.BioMed research international · 2022Article
- Prognostic Factors of Colorectal Cancer: A Comparative Study on Patients With or Without Liver Metastasis.Frontiers in oncology · 2021Article
- Noncoding RNAs in inflammation and colorectal cancer.RNA biology · 2020Article
- MiR-122 Promotes the Development of Colon Cancer by TargetingTechnology in cancer research & treatment · 2019Article
- Genetic and epigenetic alterations of colorectal cancer.Intestinal research · 2018Review
- Characterization of novel low passage primary and metastatic colorectal cancer cell lines.Oncotarget · 2016Article
- Article
- Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer.American journal of cancer research · 2015Article
- Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer.World journal of gastroenterology · 2014Review
- Investigating the different mechanisms of genotoxic and non-genotoxic carcinogens by a gene set analysis.PloS one · 2014Article
- Factors affecting the time to recurrence after radical nephrectomy for localized renal cell carcinoma.Korean journal of urology · 2013Article
- Loss of chromosome 4 correlates with better long-term survival and lower relapse rate after R0-resection of colorectal liver metastases.Journal of cancer research and clinical oncology · 2013Article
- Integrative genomics in combination with RNA interference identifies prognostic and functionally relevant gene targets for oral squamous cell carcinoma.PLoS genetics · 2013Article
- Molecular alterations associated with liver metastases development in colorectal cancer patients.British journal of cancer · 2011Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases.
methodsArray Comparative Genomic Hybridization (aCGH) was employed to asses DNA copy number changes in primary colorectal tumors of three distinctive patient groups. This included formalin-fixed, paraffin-embedded tissue of patients who developed liver metastases (LM; n = 36), metastases (PM; n = 37) and a group that remained metastases-free (M0; n = 25).A novel statistical method for identifying recurrent copy number changes, KC-SMART, was used to find specific locations of genomic aberrations specific for various groups. We created a classifier for organ specific metastases based on the aCGH data using Prediction Analysis for Microarrays (PAM).
resultsSpecifically in the tumors of primary CRC patients who subsequently developed liver metastasis, KC-SMART analysis identified genomic aberrations on chromosome 20q. LM-PAM, a shrunken centroids classifier for liver metastases occurrence, was able to distinguish the LM group from the other groups (M0&PM) with 80% accuracy (78% sensitivity and 86% specificity). The classification is predominantly based on chromosome 20q aberrations.
conclusionLiver specific CRC metastases may be predicted with a high accuracy based on specific genomic aberrations in the primary CRC tumor. The ability to predict the site of metastases is important for improvement of personalized patient management.
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