ArticleThe Journal of cell biology1990
A protein homologous to the Torpedo postsynaptic 58K protein is present at the myotendinous junction.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Localization and function of Xinα in mouse skeletal muscle.American journal of physiology. Cell physiology · 2013Article
- The development of the myotendinous junction. A review.Muscles, ligaments and tendons journal · 2012Article
- Secondary motoneurons in juvenile and adult zebrafish: axonal pathfinding errors caused by embryonic nicotine exposure.The Journal of comparative neurology · 2009Article
- Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions.The Journal of cell biology · 2003Article
- Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The actin-driven movement and formation of acetylcholine receptor clusters.The Journal of cell biology · 2000Article
- Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan.The Journal of cell biology · 1999Article
- Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle.The American journal of pathology · 1999Article
- A role of tyrosine phosphatase in acetylcholine receptor cluster dispersal and formation.The Journal of cell biology · 1998Article
- Cytoplasmic components of acetylcholine receptor clusters of cultured rat myotubes: the 58-kD protein.The Journal of cell biology · 1991Article
- Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.The Journal of cell biology · 1991Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The 58K protein is a peripheral membrane protein enriched in the acetylcholine receptor (AChR)-rich postsynaptic membrane of Torpedo electric organ. Because of its coexistence with AChRs in the postsynaptic membrane in both electrocytes and skeletal muscle, it is thought to be involved in the formation and maintenance of AChR clusters. Using an mAb against the 58K protein of Torpedo electric organ, we have identified a single protein band in SDS-PAGE analysis of Xenopus myotomal muscle with an apparent molecular mass of 48 kD. With this antibody, the distribution of this protein was examined in the myotomal muscle fibers with immunofluorescence techniques. We found that the 48K protein is concentrated at the myotendinous junctions (MTJs) of these muscle fibers. The MTJ is also enriched in talin and vinculin. By double labeling muscle fibers with antibodies against talin and the 48K protein, these two proteins were found to colocalize at the membrane invaginations of the MTJ. In cultured myotomal muscle cells, the 48K protein and talin are also colocalized at sites of membrane-myofibril interaction. The 48K protein is, however, not found at focal adhesion sites in nonmuscle cells, which are enriched in talin. These data suggest that the 48K protein is specifically involved in the interaction of myofibrillar actin filaments with the plasma membrane at the MTJ. In addition to the MTJ localization, 48K protein is also present at AChR clusters both in vivo and in vitro. Thus, this protein is shared by both the MTJ and the neuromuscular junction.
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