ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2011
Follicle-stimulating hormone and bioavailable estradiol are less important than weight and race in determining bone density in younger postmenopausal women.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program.The Journal of clinical endocrinology and metabolism · 2012Trial
- Using subject-level variability to predict time-varying outcomes: investigating the association between hormone variability and BMD trajectories over the menopausal transition.Journal of applied statistics · 2026Article
- Beyond Estrogen Deficiency: The Independent Role of FSH in Site-Specific Bone Loss in Midlife Women.Calcified tissue international · 2025Article
- Associations between hormones, metabolic markers, and bone mass in perimenopausal and postmenopausal women.Journal of bone and mineral metabolism · 2025Article
- Association of follicle-stimulating hormone with bone turnover markers and bone mineral density in Chinese women across the menopausal transition.Journal of clinical laboratory analysis · 2023Article
- Follicle-stimulating hormone is associated with low bone mass in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Article
- Review
- FSH, Bone Mass, Body Fat, and Biological Aging.Endocrinology · 2018Article
- Actions of pituitary hormones beyond traditional targets.The Journal of endocrinology · 2018Review
- The Relationship between Follicle-stimulating Hormone and Bone Health: Alternative Explanation for Bone Loss beyond Oestrogen?International journal of medical sciences · 2018Review
- Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Effect of transdermal estrogen therapy on bone mineral density in postmenopausal korean women.Journal of menopausal medicine · 2014Article
- Associations between Body Composition, Hormonal and Lifestyle Factors, Bone Turnover, and BMD.Journal of bone metabolism · 2014Article
- Changes in pituitary function with ageing and implications for patient care.Nature reviews. Endocrinology · 2013Review
- Article
- Article
- Association of Endogenous Hormones and Bone Mineral Density in Postmenopausal Women.Journal of mid-life healthArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledThe association between follicle-stimulating hormone (FSH) and bone density was tested in 111 postmenopausal women aged 50-64 years. In the multivariable analysis, weight and race were important determinants of bone mineral density. FSH, bioavailable estradiol, and other hormonal variables did not show statistically significant associations with bone density at any site.
introductionFSH has been associated with bone density loss in animal models and longitudinal studies of women. Most of these analyses have not considered the effect of weight or race.
methodsWe tested the association between FSH and bone density in younger postmenopausal women, adjusting for patient-related factors. In 111 postmenopausal women aged 50-64 years, areal bone mineral density (BMD) was measured at the lumbar spine, femoral neck, total hip, and distal radius using dual-energy X-ray absorptiometry, and volumetric BMD was measured at the distal radius using peripheral quantitative computed tomography (pQCT). Height, weight, osteoporosis risk factors, and serum hormonal factors were assessed.
resultsFSH inversely correlated with weight, bioavailable estradiol, areal BMD at the lumbar spine and hip, and volumetric BMD at the ultradistal radius. In the multivariable analysis, no hormonal variable showed a statistically significant association with areal BMD at any site. Weight was independently associated with BMD at all central sites (p < 0.001), but not with BMD or pQCT measures at the distal radius. Race was independently associated with areal BMD at all sites (p ≤ 0.008) and with cortical area at the 33% distal radius (p = 0.004).
conclusionsCorrelations between FSH and bioavailable estradiol and BMD did not persist after adjustment for weight and race in younger postmenopausal women. Weight and race were more important determinants of bone density and should be included in analyses of hormonal influences on bone.
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