ArticleChemical communications (Cambridge, England)2011
Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior.
Article in Chemical communications (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Metal surface-triggered DNAzyme catalysis for efficient DNA cleavage.Communications chemistry · 2026Article
- New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem.Nucleic acids research · 2021Article
- Nucleic Acid Catalysis under Potential Prebiotic Conditions.Chemistry, an Asian journal · 2020Review
- Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch.Nucleic acids research · 2017Article
- Theranostic DNAzymes.Theranostics · 2017Review
- Biochemical and Biophysical Understanding of Metal Ion Selectivity of DNAzymes.Inorganica chimica acta · 2016Article
- DNA Catalysis: The Chemical Repertoire of DNAzymes.Molecules (Basel, Switzerland) · 2015Review
- Pursuing DNA catalysts for protein modification.Accounts of chemical research · 2015Article
- An Efficient Catalytic DNA that Cleaves L-RNA.PloS one · 2015Article
- DNA-catalyzed lysine side chain modification.Angewandte Chemie (International ed. in English) · 2014Article
- In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity.Nucleic acids research · 2014Article
- Nucleic acid catalysis: metals, nucleobases, and other cofactors.Chemical reviews · 2014Review
- DNA-catalyzed hydrolysis of esters and aromatic amides.Journal of the American Chemical Society · 2013Article
- Small, highly active DNAs that hydrolyze DNA.Journal of the American Chemical Society · 2013Article
- DNA catalysis of a normally disfavored RNA hydrolysis reaction.Journal of the American Chemical Society · 2013Article
- Systematic evaluation of the dependence of deoxyribozyme catalysis on random region length.ACS combinatorial science · 2012Article
- Deoxyribozymes and bioinformatics: complementary tools to investigate axon regeneration.Cell and tissue research · 2012Review
- Establishing broad generality of DNA catalysts for site-specific hydrolysis of single-stranded DNA.Nucleic acids research · 2012Article
- DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates.Biochemistry · 2011Article
- Lanthanide ions as required cofactors for DNA catalysts.Chemical scienceArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A deoxyribozyme that hydrolyzes DNA phosphodiester linkages with a requirement for both Zn(2+) and Mn(2+) is switched by only two nucleotide mutations to require Zn(2+) alone, demonstrating that DNA-catalyzed DNA hydrolysis can be achieved using only one metal ion cofactor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.