ArticleJournal of neurodevelopmental disorders2010
Regional cortical volumes and congenital heart disease: a MRI study in 22q11.2 deletion syndrome.
Article in Journal of neurodevelopmental disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Executive functioning in preschoolers with 22q11.2 deletion syndrome and the impact of congenital heart defects.Journal of neurodevelopmental disorders · 2023Article
- Early visual processing and adaptation as markers of disease, not vulnerability: EEG evidence from 22q11.2 deletion syndrome, a population at high risk for schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Visual processing deficits in 22q11.2 Deletion Syndrome.NeuroImage. Clinical · 2018Article
- Reduced cortical volume and thickness and their relationship to medical and operative features in post-Fontan children and adolescents.Pediatric research · 2017Article
- Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Altered Gray Matter in Adolescents with d-Transposition of the Great Arteries.The Journal of pediatrics · 2016Article
- Epilepsy and Other Neuropsychiatric Manifestations in Children and Adolescents with 22q11.2 Deletion Syndrome.Journal of clinical neurology (Seoul, Korea) · 2016Article
- An affected core drives network integration deficits of the structural connectome in 22q11.2 deletion syndrome.NeuroImage. Clinical · 2016Article
- Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome.Biological psychiatry · 2015Article
- Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development.Progress in neurobiology · 2015Review
- Structural and functional connectivity in the default mode network in 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2015Article
- Contribution of congenital heart disease to neuropsychiatric outcome in school-age children with 22q11.2 deletion syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Action simulation in hallucination-prone adolescents.Frontiers in human neuroscience · 2013Article
- Reduced fronto-temporal and limbic connectivity in the 22q11.2 deletion syndrome: vulnerability markers for developing schizophrenia?PloS one · 2013Article
- Comparing the neural bases of self-referential processing in typically developing and 22q11.2 adolescents.Developmental cognitive neuroscience · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with congenital heart disease (CHD) who survive surgery often present impaired neurodevelopment and qualitative brain anomalies. However, the impact of CHD on total or regional brain volumes only received little attention. We address this question in a sample of patients with 22q11.2 deletion syndrome (22q11DS), a neurogenetic condition frequently associated with CHD. Sixty-one children, adolescents, and young adults with confirmed 22q11.2 deletion were included, as well as 80 healthy participants matched for age and gender. Subsequent subdivision of the patients group according to CHD yielded a subgroup of 27 patients with normal cardiac status and a subgroup of 26 patients who underwent cardiac surgery during their first years of life (eight patients with unclear status were excluded). Regional cortical volumes were extracted using an automated method and the association between regional cortical volumes, and CHD was examined within a three-condition fixed factor. Robust protection against type I error used Bonferroni correction. Smaller total cerebral volumes were observed in patients with CHD compared to both patients without CHD and controls. The pattern of bilateral regional reductions associated with CHD encompassed the superior parietal region, the precuneus, the fusiform gyrus, and the anterior cingulate cortex. Within patients, a significant reduction in the left parahippocampal, the right middle temporal, and the left superior frontal gyri was associated with CHD. The present results of global and regional volumetric reductions suggest a role for disturbed hemodynamic in the pathophysiology of brain alterations in patients with neurodevelopmental disease and cardiac malformations.
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Registered trials
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