Evidence map›Paper›PMID 21124951›Full record

ArticlePLoS computational biology2010

Untangling the Interplay between Epidemic Spread and Transmission Network Dynamics.

Christel Kamp

Abstract read
In one paragraph

Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A Review of Network Models for HIV Spread.Journal of acquired immune deficiency syndromes (1999) · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
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  9. Spread of competing viruses on heterogeneous networks.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017
    Article
  10. Article
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  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
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  18. Epidemic spread on weighted networks.PLoS computational biology · 2013
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Christel KampBiostatistics, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany. kamch@pei.de

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epidemic spread of infectious diseases is ubiquitous and often has a considerable impact on public health and economic wealth. The large variability in the spatio-temporal patterns of epidemics prohibits simple interventions and requires a detailed analysis of each epidemic with respect to its infectious agent and the corresponding routes of transmission. To facilitate this analysis, we introduce a mathematical framework which links epidemic patterns to the topology and dynamics of the underlying transmission network. The evolution, both in disease prevalence and transmission network topology, is derived from a closed set of partial differential equations for infections without allowing for recovery. The predictions are in excellent agreement with complementarily conducted agent-based simulations. The capacity of this new method is demonstrated in several case studies on HIV epidemics in synthetic populations: it allows us to monitor the evolution of contact behavior among healthy and infected individuals and the contributions of different disease stages to the spreading of the epidemic. This gives both direction to and a test bed for targeted intervention strategies for epidemic control. In conclusion, this mathematical framework provides a capable toolbox for the analysis of epidemics from first principles. This allows for fast, in silico modeling--and manipulation--of epidemics and is especially powerful if complemented with adequate empirical data for parameterization.

Indexed as

Disease Transmission, InfectiousEpidemicsEpidemiologic MethodsModels, BiologicalAlgorithmsComputational BiologyComputer SimulationHIV InfectionsHumansReproducibility of Results

Identifiers

PMID21124951
PMCPMC2987842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.