ArticlePloS one2010
Attenuated response of aged mice to respiratory Francisella novicida is characterized by reduced cell death and absence of subsequent hypercytokinemia.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Aging and lung diseases: Unraveling mechanisms and therapeutic targets.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Advances in Rodent Experimental Models of Sepsis.International journal of molecular sciences · 2023Review
- Chronically hypertensive transgenic mice expressing human AT1R haplotype-I exhibit increased susceptibility toFrontiers in microbiology · 2023Article
- Deletion Mutants ofPathogens (Basel, Switzerland) · 2021Article
- Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.Critical care (London, England) · 2019Article
- Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response.Intensive care medicine experimental · 2019Article
- Innate immune responses in the ageing lung.Clinical and experimental immunology · 2017Review
- Toll-like Receptor function of murine macrophages, probed by cytokine induction, is biphasic and is not impaired globally with age.Mechanisms of ageing and development · 2016Article
- F. novicida-Infected A. castellanii Does Not Enhance Bacterial Virulence in Mice.Frontiers in cellular and infection microbiology · 2016Article
- The future of murine sepsis and trauma research models.Journal of leukocyte biology · 2015Review
- Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.Critical care (London, England) · 2015Article
- Sepsis in old age: review of human and animal studies.Aging and disease · 2014Review
- Protective immunity and defects in the neonatal and elderly immune response to sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Aged mice are unable to mount an effective myeloid response to sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- IglC and PdpA are important for promoting Francisella invasion and intracellular growth in epithelial cells.PloS one · 2014Article
- MyD88-dependent signaling prolongs survival and reduces bacterial burden during pulmonary infection with virulent Francisella tularensis.The American journal of pathology · 2013Article
- Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia.PloS one · 2013Article
- Members of the Francisella tularensis phagosomal transporter subfamily of major facilitator superfamily transporters are critical for pathogenesis.Infection and immunity · 2012Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPneumonia and pulmonary infections are major causes of mortality among the growing elderly population. Age associated attenuations of various immune parameters, involved with both innate and adaptive responses are collectively known as immune senescence. These changes are likely to be involved with differences in host susceptibility to disease between young and aged individuals. METHODOLOGY/PRINCIPAL
findingsThe objective of this study was to assess potential age related differences in the pulmonary host response in mice to the Gram-negative respiratory pathogen, Francisella novicida. We intranasally infected mice with F. novicida and compared various immune and pathological parameters of the pulmonary host response in both young and aged mice. CONCLUSIONS/SIGNIFICANCE: We observed that 20% of aged mice were able to survive an intranasal challenge with F. novicida while all of their younger cohorts died consistently within 4 to 6 days post infection. Further experiments revealed that all of the aged mice tested were initially able to control bacterial replication in the lungs as well as at distal sites of replication compared with young mice. In addition, the small cohort of aged survivors did not progress to a severe sepsis syndrome with hypercytokinemia, as did all of the young adult mice. Finally, a lack of widespread cell death in potential aged survivors coupled with a difference in cell types recruited to sites of infection within the lung confirmed an altered host response to Francisella in aged mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.