ArticlePloS one2010
Exploring cell tropism as a possible contributor to influenza infection severity.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials.Expert review of anti-infective therapy · 2017Pooled it
- Deliberating the scientific evidence base for influenza transmission to raw milk consumers.Risk analysis : an official publication of the Society for Risk Analysis · 2025Review
- The long reach of influenza and other respiratory viruses: from acute epithelial injury to post-viral lung disease.Clinical microbiology reviews · 2025Review
- Introducing a framework for within-host dynamics and mutations modelling of H5N1 influenza infection in humans.Journal of the Royal Society, Interface · 2025Article
- A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity.Virologica Sinica · 2025Article
- Review
- Dynamical characterization of antiviral effects in COVID-19.Annual reviews in control · 2021Article
- A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract.PLoS computational biology · 2020Article
- A comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting time.PloS one · 2018Article
- Investigating Different Mechanisms of Action in Combination Therapy for Influenza.Frontiers in pharmacology · 2018Article
- Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms.PloS one · 2017Article
- Understanding the within-host dynamics of influenza A virus: from theory to clinical implications.Journal of the Royal Society, Interface · 2016Article
- Within-Host Models of High and Low Pathogenic Influenza Virus Infections: The Role of Macrophages.PloS one · 2016Article
- Review
- Towards multiscale modeling of influenza infection.Journal of theoretical biology · 2013Article
- Assessing mathematical models of influenza infections using features of the immune response.PloS one · 2013Article
- Reducing uncertainty in within-host parameter estimates of influenza infection by measuring both infectious and total viral load.PloS one · 2013Article
- Influenza A viruses target type II pneumocytes in the human lung.The Journal of infectious diseases · 2012Article
- Article
- A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead.BMC public health · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several mechanisms have been proposed to account for the marked increase in severity of human infections with avian compared to human influenza strains, including increased cytokine expression, poor immune response, and differences in target cell receptor affinity. Here, the potential effect of target cell tropism on disease severity is studied using a mathematical model for in-host influenza viral infection in a cell population consisting of two different cell types. The two cell types differ only in their susceptibility to infection and rate of virus production. We show the existence of a parameter regime which is characterized by high viral loads sustained long after the onset of infection. This finding suggests that differences in cell tropism between influenza strains could be sufficient to cause significant differences in viral titer profiles, similar to those observed in infections with certain strains of influenza A virus. The two target cell mathematical model offers good agreement with experimental data from severe influenza infections, as does the usual, single target cell model albeit with biologically unrealistic parameters. Both models predict that while neuraminidase inhibitors and adamantanes are only effective when administered early to treat an uncomplicated seasonal infection, they can be effective against more severe influenza infections even when administered late.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.