ArticlePLoS biology2010
Regulation of Na+/K+ ATPase transport velocity by RNA editing.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- The electrogenicity of the NaeLife · 2025Article
- RNA editing generates mRNA isoforms with distinct stabilities that may expand the thermal tolerance of mRNA and proteins inZoological research · 2025Article
- A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Creation of an albino squid line by CRISPR-Cas9 and its application for in vivo functional imaging of neural activity.Current biology : CB · 2023Article
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- Squid express conserved ADAR orthologs that possess novel features.Frontiers in genome editing · 2023Article
- Disease mutations of human α3 NaPNAS nexus · 2022Article
- Adaptive Proteome Diversification by Nonsynonymous A-to-I RNA Editing in Coleoid Cephalopods.Molecular biology and evolution · 2021Article
- Transient Electrical Currents Mediated by the NaBiophysical journal · 2020Review
- Spatially regulated editing of genetic information within a neuron.Nucleic acids research · 2020Article
- The Effect of Two Amino acid Residue Substitutions via RNA Editing on Dark-operative Protochlorophyllide Oxidoreductase in the Black Pine Chloroplasts.Scientific reports · 2017Article
- Understanding RNA modifications: the promises and technological bottlenecks of the 'epitranscriptome'.Open biology · 2017Review
- Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.Nature communications · 2015Article
- The emerging role of RNA editing in plasticity.The Journal of experimental biology · 2015Review
- Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus).BMC genomics · 2015Article
- Regulation of Ion Channel and Transporter Function Through RNA Editing.Current issues in molecular biology · 2015Review
- Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system.Frontiers in neuroscience · 2013Article
- A role for A-to-I RNA editing in temperature adaptation.Physiology (Bethesda, Md.) · 2012Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Because firing properties and metabolic rates vary widely, neurons require different transport rates from their Na(+)/K(+) pumps in order to maintain ion homeostasis. In this study we show that Na(+)/K(+) pump activity is tightly regulated by a novel process, RNA editing. Three codons within the squid Na(+)/K(+) ATPase gene can be recoded at the RNA level, and the efficiency of conversion for each varies dramatically, and independently, between tissues. At one site, a highly conserved isoleucine in the seventh transmembrane span can be converted to a valine, a change that shifts the pump's intrinsic voltage dependence. Mechanistically, the removal of a single methyl group specifically targets the process of Na(+) release to the extracellular solution, causing a higher turnover rate at the resting membrane potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.