ArticlePloS one2010
Functional identification of neuroprotective molecules.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Cryo-EM structure of AAA + ATPase thorase reveals novel helical filament formation.Computational and structural biotechnology journal · 2025Article
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- AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1.Nature communications · 2022Article
- Activation of the Akt1-CREB pathway promotesScience signaling · 2020Article
- Congenital immobility and stiffness related to biallelicNeurology. Genetics · 2020Article
- Differentially Expressed Genes and Their Clinical Significance in Ischaemic Stroke: An In-Silico Study.The Malaysian journal of medical sciences : MJMS · 2020Article
- AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF.Cell reports · 2020Article
- Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors.Biomolecules · 2020Review
- Absence of miRNA-146a Differentially Alters Microglia Function and Proteome.Frontiers in immunology · 2020Article
- The AAA + ATPase Thorase is neuroprotective against ischemic injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch.Journal of neuroinflammation · 2019Article
- Coupling of microtubule motors with AP-3 generated organelles in axons by NEEP21 family member calcyon.Molecular biology of the cell · 2018Article
- Presenilin1/γ-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models.Oncotarget · 2017Article
- A Systematic RNAi Screen of Neuroprotective Genes Identifies Novel Modulators of Alpha-Synuclein-Associated Effects in Transgenic Caenorhabditis elegans.Molecular neurobiology · 2016Article
- Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity.The European journal of neuroscience · 2016Article
- Article
- Tolerance to ischemia - an increasingly complex biology.Translational stroke research · 2013Review
- Botch promotes neurogenesis by antagonizing Notch.Developmental cell · 2012Article
- A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the brain possesses a wide and diverse repertoire of neuroprotective genes. Further characterization of these and other protective signals could provide new treatment opportunities for neurological injury from ischemia or neurodegenerative disease.
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Registered trials
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