ArticlePloS one2010
Maturation-dependent licensing of naive T cells for rapid TNF production.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluating the inhibition of IL-17A and TNFα in a cartilage explant model cultured with Th17-derived cytokines.Journal of translational autoimmunity · 2024Article
- Differential tumor immune microenvironment coupled with tumor progression or tumor eradication in HPV-antigen expressing squamous cell carcinoma (SCC) models.Frontiers in immunology · 2024Article
- T cells at work: How post-transcriptional mechanisms control T cell homeostasis and activation.European journal of immunology · 2021Review
- Sex Differences in the Immune System Become Evident in the Perinatal Period in the Four Core Genotypes Mouse.Frontiers in endocrinology · 2021Article
- Clonal expansion of innate and adaptive lymphocytes.Nature reviews. Immunology · 2020Review
- Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15International journal of molecular sciences · 2020Article
- Building a T cell compartment: how immune cell development shapes function.Nature reviews. Immunology · 2020Review
- Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Treg-specific deletion of NKAP results in severe, systemic autoimmunity due to peripheral loss of Tregs.Journal of autoimmunity · 2018Article
- Reinterpreting recent thymic emigrant function: defective or adaptive?Current opinion in immunology · 2018Review
- T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy.JCI insight · 2018Article
- Cutting Edge: Defective Aerobic Glycolysis Defines the Distinct Effector Function in Antigen-Activated CD8Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Recent thymic emigrants are tolerized in the absence of inflammation.The Journal of experimental medicine · 2016Article
- Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.Nature immunology · 2016Article
- An Essential Role for the Transcription Factor Runx1 in T Cell Maturation.Scientific reports · 2016Article
- Cutting Edge: Enhanced Clonal Burst Size Corrects an Otherwise Defective Memory Response by CD8+ Recent Thymic Emigrants.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- T Cell Adolescence: Maturation Events Beyond Positive Selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Histone Deacetylase 3 Is Required for T Cell Maturation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants.Computational and structural biotechnology journal · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The peripheral naïve T cell pool is comprised of a heterogeneous population of cells at various stages of development, which is a process that begins in the thymus and is completed after a post-thymic maturation phase in the periphery. One hallmark of naïve T cells in secondary lymphoid organs is their unique ability to produce TNF rapidly after activation and prior to acquiring other effector functions. To determine how maturation influences the licensing of naïve T cells to produce TNF, we compared cytokine profiles of CD4(+) and CD8(+) single positive (SP) thymocytes, recent thymic emigrants (RTEs) and mature-naïve (MN) T cells during TCR activation. SP thymocytes exhibited a poor ability to produce TNF when compared to splenic T cells despite expressing similar TCR levels and possessing comparable activation kinetics (upregulation of CD25 and CD69). Provision of optimal antigen presenting cells from the spleen did not fully enable SP thymocytes to produce TNF, suggesting an intrinsic defect in their ability to produce TNF efficiently. Using a thymocyte adoptive transfer model, we demonstrate that the ability of T cells to produce TNF increases progressively with time in the periphery as a function of their maturation state. RTEs that were identified in NG-BAC transgenic mice by the expression of GFP showed a significantly enhanced ability to express TNF relative to SP thymocytes but not to the extent of fully MN T cells. Together, these findings suggest that TNF expression by naïve T cells is regulated via a gradual licensing process that requires functional maturation in peripheral lymphoid organs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.