ArticlePLoS genetics2010
CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Coordinated evolution of the SNORD115 and SNORD116 tandem repeats at the imprinted Prader-Willi/Angelman locus.NAR molecular medicine · 2024Article
- Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.Genome medicine · 2020Article
- Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele.Epigenetics & chromatin · 2018Article
- The origin of imprinting defects in Temple syndrome and comparison with other imprinting disorders.Epigenetics · 2018Article
- Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations.Nature communications · 2017Article
- Role of HOTAIR in the diagnosis and prognosis of acute leukemia.Oncology reports · 2016Article
- Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.Genome biology · 2015Article
- Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Human molecular genetics · 2014Article
- Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencing.Nucleic acids research · 2014Article
- Cross-talk between site-specific transcription factors and DNA methylation states.The Journal of biological chemistry · 2013Review
- The boundary of the meristematic and elongation zones in roots: endoreduplication precedes rapid cell expansion.Scientific reports · 2013Article
- De novo DNA methylation in the male germ line occurs by default but is excluded at sites of H3K4 methylation.Cell reports · 2013Article
- DNA methylation: roles in mammalian development.Nature reviews. Genetics · 2013Review
- Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline.Human reproduction (Oxford, England) · 2013Article
- Genomic imprinting: recognition and marking of imprinted loci.Current opinion in genetics & development · 2012Review
- Transcription and histone methylation changes correlate with imprint acquisition in male germ cells.The EMBO journal · 2012Article
- Article
- Chromatin immunoprecipitation to characterize the epigenetic profiles of imprinted domains.Methods in molecular biology (Clifton, N.J.) · 2012Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Genomic imprints-parental allele-specific DNA methylation marks at the differentially methylated regions (DMRs) of imprinted genes-are erased and reestablished in germ cells according to the individual's sex. Imprint establishment at paternally methylated germ line DMRs occurs in fetal male germ cells. In prospermatogonia, the two unmethylated alleles exhibit different rates of de novo methylation at the H19/Igf2 imprinting control region (ICR) depending on parental origin. We investigated the nature of this epigenetic memory using bisulfite sequencing and allele-specific ChIP-SNuPE assays. We found that the chromatin composition in fetal germ cells was biased at the ICR between the two alleles with the maternally inherited allele exhibiting more H3K4me3 and less H3K9me3 than the paternally inherited allele. We determined genetically that the chromatin bias, and also the delayed methylation establishment in the maternal allele, depended on functional CTCF insulator binding sites in the ICR. Our data suggest that, in primordial germ cells, maternally inherited allele-specific CTCF binding sets up allele-specific chromatin differences at the ICR. The erasure of these allele-specific chromatin marks is not complete before the process of de novo methylation imprint establishment begins. CTCF-dependent allele-specific chromatin composition imposes a maternal allele-specific delay on de novo methylation imprint establishment at the H19/Igf2 ICR in prospermatogonia.
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