ArticlePloS one2010
Freshwater sponges have functional, sealing epithelia with high transepithelial resistance and negative transepithelial potential.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Early transitions in the evolution of cognition.History and philosophy of the life sciences · 2025Article
- Clinical dermatoendocrinology: saving lives by looking at the skin.Archives of endocrinology and metabolism · 2025Review
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- Epithelia Are Scaffolds for Electricity-Dependent Molecular Interactions.Reviews of physiology, biochemistry and pharmacology · 2025Review
- The Buds of Oscarella lobularis (Porifera, Homoscleromorpha): A New Convenient Model for Sponge Cell and Evolutionary Developmental Biology.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Origin and development of primary animal epithelia.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Article
- The origin of human epithelial tissue.Histology and histopathology · 2023Review
- The developmental biology ofScience advances · 2021Article
- p73 as a Tissue Architect.Frontiers in cell and developmental biology · 2021Review
- A non-bilaterian perspective on the development and evolution of animal digestive systems.Cell and tissue research · 2019Review
- Bodily Complexity: Integrated Multicellular Organizations for Contraction-Based Motility.Frontiers in physiology · 2019Article
- Analysis of a vinculin homolog in a sponge (phylum Porifera) reveals that vertebrate-like cell adhesions emerged early in animal evolution.The Journal of biological chemistry · 2018Article
- New genomic data and analyses challenge the traditional vision of animal epithelium evolution.BMC genomics · 2018Article
- In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms.BMC developmental biology · 2017Article
- Article
- Origin of animal multicellularity: precursors, causes, consequences-the choanoflagellate/sponge transition, neurogenesis and the Cambrian explosion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Occluding junctions of invertebrate epithelia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Emerging Sponge Models of Animal-Microbe Symbioses.Frontiers in microbiology · 2016Review
- A unique alkaline pH-regulated and fatty acid-activated tandem pore domain potassium channel (K₂P) from a marine sponge.The Journal of experimental biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial tissue - the sealed and polarized layer of cells that regulates transport of ions and solutes between the environment and the internal milieu - is a defining characteristic of the Eumetazoa. Sponges, the most ancient metazoan phylum, are generally believed to lack true epithelia, but their ability to occlude passage of ions has never been tested. Here we show that freshwater sponges (Demospongiae, Haplosclerida) have functional epithelia with high transepithelial electrical resistance (TER), a transepithelial potential (TEP), and low permeability to small-molecule diffusion. Curiously, the Amphimedon queenslandica sponge genome lacks the classical occluding genes [5] considered necessary to regulate sealing and control of ion transport. The fact that freshwater sponge epithelia can seal suggests that either occluding molecules have been lost in some sponge lineages, or demosponges use novel molecular complexes for epithelial occlusion; if the latter, it raises the possibility that mechanisms for occlusion used by sponges may exist in other metazoa. Importantly, our results imply that functional epithelia evolved either several times, or once, in the ancestor of the Metazoa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.