ArticlePloS one2010
The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Kisspeptin Is Upregulated at the Maternal-Fetal Interface of the Preeclamptic-like BPH/5 Mouse and Normalized after Synchronization of Sex Steroid Hormones.Reproductive medicine (Basel, Switzerland) · 2022Article
- Small RNA profiling of low biomass samples: identification and removal of contaminants.BMC biology · 2018Article
- Integrated analysis of mRNA and viral miRNAs in the kidney of Carassius auratus gibelio response to cyprinid herpesvirus 2.Scientific reports · 2017Article
- Genome-wide analysis and functional prediction of long non-coding RNAs in mouse uterus during the implantation window.Oncotarget · 2017Article
- Embryo implantation evolved from an ancestral inflammatory attachment reaction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Identification and profiling of microRNAs in goat endometrium during embryo implantation.PloS one · 2015Article
- Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4.The Journal of biological chemistry · 2014Article
- Progesterone regulates secretin expression in mouse uterus during early pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Mmu-miR-193 is involved in embryo implantation in mouse uterus by regulating GRB7 gene expression.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- The onset of human ectopic pregnancy demonstrates a differential expression of miRNAs and their cognate targets in the Fallopian tube.International journal of clinical and experimental pathology · 2014Article
- Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- MicroRNAs--mediators of myometrial contractility during pregnancy and labour.Nature reviews. Endocrinology · 2013Review
- OxymiRs in cutaneous development, wound repair and regeneration.Seminars in cell & developmental biology · 2012Review
- Article
- Minireview: The roles of small RNA pathways in reproductive medicine.Molecular endocrinology (Baltimore, Md.) · 2011Review
- miRanalyzer: an update on the detection and analysis of microRNAs in high-throughput sequencing experiments.Nucleic acids research · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelayed implantation is a developmental arrest at the blastocyst stage and a good model for embryo implantation. MicroRNAs (miRNAs) have been shown to be involved in mouse embryo implantation through regulating uterine gene expression. This study was to have an integrative analysis on global miRNA and mRNA expression in mouse uterus under delayed implantation and activation through Illumina sequencing. METHODOLOGY/PRINCIPAL
findingsBy deep sequencing and analysis, we found that there are 20 miRNAs up-regulated and 42 miRNAs down-regulated at least 1.2 folds, and 268 genes up-regulated and 295 genes down-regulated at least 2 folds under activation compared to delayed implantation, respectively. Many different forms of editing in mature miRNAs are detected. The percentage of editing at positions 4 and 5 of mature miRNAs is significantly higher under delayed implantation than under activation. Although the number of miR-21 reference sequence under activation is slightly lower than that under delayed implantation, the total level of miR-21 under activation is higher than that under delayed implantation. Six novel miRNAs are predicted and confirmed. The target genes of significantly up-regulated miRNAs under activation are significantly enriched.
conclusionsmiRNA and mRNA expression patterns are closely related. The target genes of up-regulated miRNAs are significantly enriched. A high level of editing at positions 4 and 5 of mature miRNAs is detected under delayed implantation than under activation. Our data should be valuable for future study on delayed implantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.