ArticleMucosal immunology2011
Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica.
Article in Mucosal immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 122 citations in OpenAlex.
- Association of circulating leptin concentration with the risk of Clostridium difficile colitis and exploration of their associated mediators: A mendelian randomisation study.Journal, genetic engineering & biotechnology · 2026Article
- Optimizing a carbon source based on water temperature to reduceFrontiers in systems biology · 2026Article
- Leptin receptor gene influences pig gut microbiota both through feed intake and independently.Animal microbiome · 2025Article
- Serum levels of Interleukin-10, Interleukin-6, and leptin in patients with Mycobacterium leprae-Helminth Co-Infections.BMC infectious diseases · 2025Observational
- Interplay of obesity and parasitic infection: current evidence of immunogenesis, tumorigenesis and leptin receptor involvement.Nutrition & metabolism · 2025Review
- Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production.The Journal of infectious diseases · 2024Article
- Relationship between leptin and white blood cells: a potential role in infection susceptibility and severity-the Olivetti Heart Study.Internal and emergency medicine · 2023Article
- Sex Difference in Amebiasis.Current topics in microbiology and immunology · 2023Article
- Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort.The American journal of tropical medicine and hygiene · 2022Article
- Protective Effects of High-Fat Diet against Murine Colitis in Association with Leptin Signaling and Gut Microbiome.Life (Basel, Switzerland) · 2022Article
- Effect of Caging onMicroorganisms · 2022Article
- Leptin Signaling in Obesity and Colorectal Cancer.International journal of molecular sciences · 2022Review
- Histological Changes and Ghrelin, P-Selectin, and Leptin Parameter in Patients with Hepatic Hydatidosis in Iraq.Archives of Razi Institute · 2022Article
- A transcriptomics-guided drug target discovery strategy identifies receptor ligands for lung regeneration.Science advances · 2022Article
- Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle.Frontiers in nutrition · 2022Review
- Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases.International journal of biological sciences · 2022Review
- The molecular interplay of the establishment of an infection - gene expression of Diaphorina citri gut and Candidatus Liberibacter asiaticus.BMC genomics · 2021Article
- Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis.Mucosal immunology · 2021Article
- Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?International journal of molecular sciences · 2021Review
- Host Protective Mechanisms to Intestinal Amebiasis.Trends in parasitology · 2021Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show that mice lacking the functional leptin receptor developed devastating mucosal destruction after E. histolytica infection. Bone marrow chimera experiments demonstrated that leptin receptor expressed on hematopoietic cells was not sufficient to confer resistance. Similarly, peripheral knockout of the leptin receptor rendered animals susceptible, indicating that central expression of the leptin receptor was not sufficient to confer protection. The site of leptin action was localized to the gut via an intestinal epithelium-specific deletion of the leptin receptor, which rendered mice susceptible to infection and mucosal destruction by the parasite. Mutation of tyrosine 985 or 1138 in the intracellular domain of the leptin receptor, which mediates signaling through the SH2-containing tyrosine phosphatase/extracellular signal-regulated kinase (SHP2/ERK) and signal transducer and activator of transcription 3 (STAT3) pathways, respectively, demonstrated that both were important for mucosal protection. We conclude that leptin-mediated resistance to amebiasis is via its actions on intestinal epithelium rather than hematopoietic cells or the brain, and requires leptin receptor signaling through both the STAT3 and SHP2/ERK pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.