ArticleGenome biology and evolution2011
The antiquity of chordate odorant receptors is revealed by the discovery of orthologs in the cnidarian Nematostella vectensis.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
- Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.Zoological letters · 2026Article
- The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies.International journal of molecular sciences · 2024Review
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- Chemical communication and its role in sexual selection across Animalia.Communications biology · 2023Review
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- The evolutionary origins of the vertebrate olfactory system.Open biology · 2020Review
- Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus.BMC genomics · 2020Article
- Holothurians have a reduced GPCR and odorant receptor-like repertoire compared to other echinoderms.Scientific reports · 2020Article
- Transcriptome-wide analysis of differential gene expression in response to light:dark cycles in a model cnidarian.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2018Article
- Hedgehog signaling regulates ciliary localization of mouse odorant receptors.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The cellular and molecular basis of cnidarian neurogenesis.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Article
- A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning.Nature communications · 2015Article
- Systematic study on G-protein couple receptor prototypes: did they really evolve from prokaryotic genes?IET systems biology · 2014Article
- Article
- Sensing marine biomolecules: smell, taste, and the evolutionary transition from aquatic to terrestrial life.Frontiers in chemistry · 2014Article
- Mutual influences between the main olfactory and vomeronasal systems in development and evolution.Frontiers in neuroanatomy · 2012Article
- Characterization of circadian behavior in the starlet sea anemone, Nematostella vectensis.PloS one · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In vertebrates, olfaction is mediated by several families of G protein-coupled receptors (GPCRs) including odorant receptors (ORs). In this study, we investigated the antiquity of OR genes by searching for amino acid motifs found in chordate ORs among the protein predictions from 12 nonchordate species. Our search uncovered a novel group of genes in the cnidarian Nematostella vectensis. Phylogenetic analysis that included representatives from the other major lineages of rhodopsin-like GPCRs showed that the cnidarian genes, the cephalochordate and vertebrate ORs, and a family of genes from the echinoderm, Strongylocentrotus purpuratus, form a monophyletic clade. The taxonomic distribution of these genes indicates that the formation of this clade and therefore the diversification of the rhodopsin-like GPCR family began at least 700 million years ago, prior to the divergence of cnidarians and bilaterians. ORs and other rhodopsin-like GPCRs have roles in cell migration, axon guidance, and neurite growth; therefore, duplication and divergence in this family may have played a key role in the evolution of cell type diversity (including the emergence of complex nervous systems) and in the evolution of metazoan body plan diversity.
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