ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Role of spinal V1a receptors in regulation of arterial pressure during acute and chronic osmotic stress.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Afferent innervation of the kidney: projections to and processing in the central nervous system.Frontiers in physiology · 2025Review
- Contributions of afferent and sympathetic renal nerves to cystogenesis and arterial pressure regulation in a preclinical model of autosomal recessive polycystic kidney disease.American journal of physiology. Renal physiology · 2022Article
- Precision Targeted Ablation of Fine Neurovascular Structures In Vivo Using Dual-mode Ultrasound Arrays.Scientific reports · 2020Article
- Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.Physiological reports · 2018Article
- Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Gαi2 proteins.Acta physiologica (Oxford, England) · 2016Article
- Differential role of afferent and efferent renal nerves in the maintenance of early- and late-phase Dahl S hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Intermittent electrical stimulation of the right cervical vagus nerve in salt-sensitive hypertensive rats: effects on blood pressure, arrhythmias, and ventricular electrophysiology.Physiological reports · 2015Article
- A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- The neurogenic phase of angiotensin II-salt hypertension is prevented by chronic intracerebroventricular administration of benzamil.Physiological reports · 2014Article
- Roles of the subfornical organ and area postrema in arterial pressure increases induced by 48-h water deprivation in normal rats.Physiological reports · 2014Article
- Article
- Reversal of genetic salt-sensitive hypertension by targeted sympathetic ablation.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Effects of intrathecal kynurenate on arterial pressure during chronic osmotic stress in conscious rats.American journal of physiology. Heart and circulatory physiology · 2013Article
- Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.PloS one · 2013Article
- Effect of global and regional sympathetic blockade on arterial pressure during water deprivation in conscious rats.American journal of physiology. Heart and circulatory physiology · 2012Article
- Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics.Journal of neuroendocrinology · 2012Review
- Time-dependent changes in autonomic control of splanchnic vascular resistance and heart rate in ANG II-salt hypertension.American journal of physiology. Heart and circulatory physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vasopressinergic neurons in the paraventricular nucleus project to areas in the spinal cord from which sympathetic nerves originate. This pathway is hypothesized to be involved in the regulation of mean arterial pressure (MAP), particularly under various conditions of osmotic stress. Several studies measuring sympathetic nerve activity support this hypothesis. However, the evidence that spinal vasopressin influences MAP under physiological or pathophysiological conditions in conscious animals is limited. The purpose of this study was to investigate, in conscious rats, if the increases in MAP during acute or chronic osmotic stimuli are due to activation of spinal vasopressin (V1a) receptors. Three conditions of osmotic stress were examined: acute intravenous hypertonic saline, 24- and 48-h water deprivation, and 4 wk of DOCA-salt treatment. Rats were chronically instrumented with an indwelling catheter for intrathecal injections and a radiotelemeter to measure MAP. In normotensive rats, intrathecal vasopressin and V1a agonist increased MAP, heart rate, and motor activity; these responses were blocked by pretreatment with an intrathecal V1a receptor antagonist. However, when the intrathecal V1a antagonist was given during the three conditions of osmotic stress to investigate the role of "endogenous" vasopressin, the antagonist had no effect on MAP, heart rate, or motor activity. Contrary to the hypothesis suggested by previous studies, these findings indicate that spinal V1a receptors are not required for elevations of MAP under conditions of acute or chronic osmotic stress in conscious rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.