ArticleProceedings of the National Academy of Sciences of the United States of America2010
ANK6, a mitochondrial ankyrin repeat protein, is required for male-female gamete recognition in Arabidopsis thaliana.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 55 citations in OpenAlex.
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- Endophytic commensal bacteria capitalize on the AvrPto-FER pathway to enhance proliferation during early stages of pathogen invasion.The ISME journal · 2025Article
- Demystifying the functions of the mitochondrial ORFan proteins in bivalves with doubly uniparental inheritance.Biology letters · 2025Article
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- OsSRK1, a lectin receptor-like kinase, controls plant height by mediating internode elongation inMolecular breeding : new strategies in plant improvement · 2022Article
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- A Plastid-Bound Ankyrin Repeat Protein Controls Gametophyte and Early Embryo Development inFrontiers in plant science · 2022Article
- Identification and Analysis of Genes Involved in Double Fertilization in Rice.International journal of molecular sciences · 2021Article
- Arabidopsis JAZ Proteins Interact with and Suppress RHD6 Transcription Factor to Regulate Jasmonate-Stimulated Root Hair Development.The Plant cell · 2020Article
- EBP1 nuclear accumulation negatively feeds back on FERONIA-mediated RALF1 signaling.PLoS biology · 2018Article
- Different Modes of Gene Duplication Show Divergent Evolutionary Patterns and Contribute Differently to the Expansion of Gene Families Involved in Important Fruit Traits in Pear (Frontiers in plant science · 2018Article
- RPS9M, a Mitochondrial Ribosomal Protein, Is Essential for Central Cell Maturation and Endosperm Development inFrontiers in plant science · 2017Article
- FERONIA interacts with ABI2-type phosphatases to facilitate signaling cross-talk between abscisic acid and RALF peptide in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- In silico analyses of mitochondrial ORFans in freshwater mussels (Bivalvia: Unionoida) provide a framework for future studies of their origin and function.BMC genomics · 2016Article
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- Mitochondrial energy and redox signaling in plants.Antioxidants & redox signaling · 2013Review
- Gene expression profiles in rice gametes and zygotes: identification of gamete-enriched genes and up- or down-regulated genes in zygotes after fertilization.Journal of experimental botany · 2013Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Double fertilization in angiosperms involves several successive steps, including guidance and reception of the pollen tube and male-female gamete recognition. Each step entails extensive communication and interaction between two different reproductive cell or tissue types. Extensive research has focused on the pollen tube, namely, its interaction with the stigma and reception by maternal cells. Little is known, however, about the mechanism by which the gametes recognize each other and interact to form a zygote. We report that an ankyrin repeat protein (ANK6) is essential for fertilization, specifically for gamete recognition. ANK6 (At5g61230) was highly expressed in the male and female gametophytes before and during but not after fertilization. Genetic analysis of a T-DNA insertional mutant suggested that loss of function of ANK6 results in embryonic lethality. Moreover, male-female gamete recognition was found to be impaired only when an ank6 male gamete reached an ank6 female gamete, thereby preventing formation of homozygous zygotes. ANK6 was localized to the mitochondria, where it interacted with SIG5, a transcription initiation factor previously found to be essential for fertility. These results show that ANK6 plays a central role in male-female gamete recognition, possibly by regulating mitochondrial gene expression.
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