ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging.Molecular psychiatry · 2023Article
- Adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging.Research square · 2023Article
- The behavior and functions of embryonic microglia.Anatomical science international · 2022Review
- SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine.Genes & diseases · 2022Review
- Neural Mechanisms and Therapeutic Opportunities for Atrial Fibrillation.Methodist DeBakey cardiovascular journal · 2021Review
- Transient microglial absence assists postmigratory cortical neurons in proper differentiation.Nature communications · 2020Article
- Article
- Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification.Journal of chemical neuroanatomy · 2016Review
- Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents.Cellular and molecular neurobiology · 2015Article
- Maintenance of postmitotic neuronal cell identity.Nature neuroscience · 2014Review
- Disorders with similar clinical phenotypes reveal underlying genetic interaction: SATB2 acts as an activator of the UPF3B gene.Human genetics · 2013Article
- Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Localization and expression of VMAT2 aross mammalian species: a translational guide for its visualization and targeting in health and disease.Advances in pharmacology (San Diego, Calif.) · 2013Review
- p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.Nature neuroscience · 2011Article
- Roles of SATB2 in osteogenic differentiation and bone regeneration.Tissue engineering. Part A · 2011Article
- Cytokines inhibit norepinephrine transporter expression by decreasing Hand2.Molecular and cellular neurosciences · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sympathetic neurons can switch their neurotransmitter phenotype from noradrenergic to cholinergic on exposure to neuropoietic cytokines in vitro and in vivo. Here, we provide evidence that this transspecification is regulated by the chromatin architecture protein Satb2. Treatment with the neuropoietic cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor rapidly and strongly increases Satb2 transcript and protein levels in cultures of rat superior cervical ganglia neurons. Knockdown of endogenous Satb2 by short interfering RNA prevents the upregulation of choline acetyltransferase (Chat) and vesicular acetylcholine transporter (Vacht) by CNTF as well as the loss of norepinephrine transporter (Net). Conversely, overexpression of Satb2 in the noradrenergic sympathetic phenotype results in a marked increase of Chat and Vacht expression and reduced Net mRNA levels in the absence of neuropoietic cytokines. Chromatin immunoprecipitation analysis in primary sympathetic neurons reveals that Satb2 binds to matrix attachment regions (MARs) within the Chat locus. In vivo, in the rat stellate ganglion, Satb2 is expressed exclusively in sudomotor cholinergic neurons innervating the sweat glands and only after establishment of contact between neurons and target. These findings demonstrate a function of the MAR-binding protein Satb2 in growth factor-dependent neurotransmitter plasticity in postmitotic neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.