ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Emergent dynamics of fast ripples in the epileptic hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.
- GABAFrontiers in neural circuits · 2022Pooled it
- Effects of a Single Session 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT.Psychophysiology · 2025Trial
- Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Epileptogenicity alters intrahippocampal ripple propagation.medRxiv : the preprint server for health sciences · 2026Article
- Astrocyte-induced dynamics of a pyramidal cell with a dendrite-connected astrocyte.Journal of computational neuroscience · 2026Article
- Article
- Fast ripple-delta coupling as an early biomarker for post-traumatic epileptogenesis in repetitive brain injury.Epilepsia open · 2026Article
- Opposing interictal dynamics in Alzheimer's disease and epilepsy.Progress in neurobiology · 2026Article
- Collapsing Perisomatic Inhibition Leads to Epileptic Fast-Ripple Oscillations Caused by Pseudosynchronous Firing of CA3 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Fast Ripple-Delta Coupling as Early Biomarker for Post-Traumatic Epileptogenesis in Repetitive Brain Injury.bioRxiv : the preprint server for biology · 2025Article
- Investigation of the relationship between 0.5-1200 Hz signal characteristics of cortical high-frequency oscillations and epileptogenicity through multivariate analysis.Epilepsy & behavior reports · 2025Article
- The role of electroencephalography in epilepsy research-From seizures to interictal activity and comorbidities.Epilepsia · 2025Review
- Review
- High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?Brain : a journal of neurology · 2024Review
- Simulated resections and RNS placement can optimize post-operative seizure outcomes when guided by fast ripple networks.medRxiv : the preprint server for health sciences · 2024Article
- A machine learning toolbox for the analysis of sharp-wave ripples reveals common waveform features across species.Communications biology · 2024Article
- Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer.Epilepsia · 2024Article
- Tuning Microelectrodes' Impedance to Improve Fast Ripples Recording.Bioengineering (Basel, Switzerland) · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Simulated resections and responsive neurostimulator placement can optimize postoperative seizure outcomes when guided by fast ripple networks.Brain communications · 2024Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fast ripples are a type of transient high-frequency oscillations recorded from the epileptogenic regions of the hippocampus and the temporal cortex of epileptic humans and rodents. These events presumably reflect hypersynchronous bursting of pyramidal cells. However, the oscillatory spectral content of fast ripples varies from 250 to 800 Hz, well above the maximal firing frequency of most hippocampal pyramidal neurons. How such high-frequency oscillations are generated is therefore unclear. Here, we combine computational simulations of fast ripples with multisite and juxtacellular recordings in vivo to examine the underlying mechanisms in the hippocampus of epileptic rats. We show that populations of bursting cells firing individually at 100-400 Hz can create fast ripples according to two main firing regimes: (1) in-phase synchronous firing resulting in "pure" fast ripples characterized by single spectral peaks that reflect single-cell behavior and (2) out-of-phase firing that results in "emergent" fast ripples. Using simulations, we found that fast ripples generated under these two different regimes can be quantitatively separated by their spectral characteristics, and we took advantage of this separability to examine their dynamics in vivo. We found that in-phase firing can reach frequencies up to 300 Hz in the CA1 and up to 400 Hz in the dentate gyrus. The organization of out-of-phase firing is determined by firing delays between cells discharging at low frequencies. The two firing regimes compete dynamically, alternating randomly from one fast ripple event to the next, and they reflect the functional dynamic organization of the different regions of the hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.