ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
H-reflex up-conditioning encourages recovery of EMG activity and H-reflexes after sciatic nerve transection and repair in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Frequency-dependent effects of superimposed NMES on spinal excitability in upper and lower limb muscles.Heliyon · 2024Article
- Structural Preservation Does Not Ensure Function at Sensory Ia-Motoneuron Synapses following Peripheral Nerve Injury and Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- ABiomedical signal processing and control · 2021Article
- Acquisition, Maintenance, and Therapeutic Use of a Simple Motor Skill.Current opinion in behavioral sciences · 2018Article
- Increased intensity and reduced frequency of EMG signals from feline self-reinnervated ankle extensors during walking do not normalize excessive lengthening.Journal of neurophysiology · 2016Article
- Ablation of the inferior olive prevents H-reflex down-conditioning in rats.Journal of neurophysiology · 2016Article
- Article
- Electrocorticographic activity over sensorimotor cortex and motor function in awake behaving rats.Journal of neurophysiology · 2015Article
- Restoring walking after spinal cord injury: operant conditioning of spinal reflexes can help.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2015Review
- Targeted neuroplasticity for rehabilitation.Progress in brain research · 2015Review
- Neuronal BDNF signaling is necessary for the effects of treadmill exercise on synaptic stripping of axotomized motoneurons.Neural plasticity · 2015Article
- Persistent beneficial impact of H-reflex conditioning in spinal cord-injured rats.Journal of neurophysiology · 2014Article
- The simplest motor skill: mechanisms and applications of reflex operant conditioning.Exercise and sport sciences reviews · 2014Review
- Locomotor impact of beneficial or nonbeneficial H-reflex conditioning after spinal cord injury.Journal of neurophysiology · 2014Article
- Operant conditioning of spinal reflexes: from basic science to clinical therapy.Frontiers in integrative neuroscience · 2014Review
- Operant conditioning of a spinal reflex can improve locomotion after spinal cord injury in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Enhancing recovery from peripheral nerve injury using treadmill training.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2011Review
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Operant conditioning of the spinal stretch reflex or its electrical analog, the H-reflex, produces spinal cord plasticity and can thereby affect motoneuron responses to primary afferent input. To explore whether this conditioning can affect the functional outcome after peripheral nerve injury, we assessed the effect of up-conditioning soleus (SOL) H-reflex on SOL and tibialis anterior (TA) function after sciatic nerve transection and repair. Sprague Dawley rats were implanted with EMG electrodes in SOL and TA and stimulating cuffs on the posterior tibial nerve. After control data collection, the sciatic nerve was transected and repaired and the rat was exposed for 120 d to continued control data collection (TC rats) or SOL H-reflex up-conditioning (TU rats). At the end of data collection, motoneurons that had reinnervated SOL and TA were labeled retrogradely. Putative primary afferent terminals [i.e., terminals containing vesicular glutamate transporter-1 (VGLUT1)] on SOL motoneurons were studied immunohistochemically. SOL (and probably TA) background EMG activity recovered faster in TU rats than in TC rats, and the final recovered SOL H-reflex was significantly larger in TU than in TC rats. TU and TC rats had significantly fewer labeled motoneurons and higher proportions of double-labeled motoneurons than untransected rats. VGLUT1 terminals were significantly more numerous on SOL motoneurons of TU than TC rats. Combined with the larger H-reflexes in TU rats, this anatomical finding supports the hypothesis that SOL H-reflex up-conditioning strengthened primary afferent reinnervation of SOL motoneurons. These results suggest that H-reflex up-conditioning may improve functional recovery after nerve injury and repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.