ArticleAmerican journal of physiology. Renal physiology2011
Evidence for net renal tubule oxalate secretion in patients with calcium kidney stones.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives.Biomedicines · 2023Review
- Primary hyperoxaluria type 1: pathophysiology and genetics.Clinical kidney journal · 2022Review
- Is It Time to Retire the Low-Oxalate Diet? No!Journal of endourology · 2021Article
- Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion.Nutrients · 2020Review
- Dietary Oxalate Intake and Kidney Outcomes.Nutrients · 2020Review
- Future treatments for hyperoxaluria.Current opinion in urology · 2020Review
- Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective.Nutrients · 2020Review
- Evidence for disordered acid-base handling in calcium stone-forming patients.American journal of physiology. Renal physiology · 2020Article
- Sodium Oxalate-Induced Acute Kidney Injury Associated With Glomerular and Tubulointerstitial Damage in Rats.Frontiers in physiology · 2020Article
- Immunity, microbiota and kidney disease.Nature reviews. Nephrology · 2019Review
- Dietary oxalate and kidney stone formation.American journal of physiology. Renal physiology · 2019Review
- Mechanism for higher urine pH in normal women compared with men.American journal of physiology. Renal physiology · 2018Article
- Idiopathic hypercalciuria and formation of calcium renal stones.Nature reviews. Nephrology · 2016Review
- Sex differences in proximal and distal nephron function contribute to the mechanism of idiopathic hypercalcuria in calcium stone formers.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Primary and secondary hyperoxaluria: Understanding the enigma.World journal of nephrology · 2015Review
- Association study of DGKH gene polymorphisms with calcium oxalate stone in Chinese population.Urolithiasis · 2014Article
- Persistence of 1,25D-induced hypercalciuria in alendronate-treated genetic hypercalciuric stone-forming rats fed a low-calcium diet.American journal of physiology. Renal physiology · 2014Article
- Body fat content and distribution and urinary risk factors for nephrolithiasis.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- A test of the hypothesis that oxalate secretion produces proximal tubule crystallization in primary hyperoxaluria type I.American journal of physiology. Renal physiology · 2013Article
- 1,25(OH)₂D₃-enhanced hypercalciuria in genetic hypercalciuric stone-forming rats fed a low-calcium diet.American journal of physiology. Renal physiology · 2013Article
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5 authors at 2 institutions in 1 country.
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Abstract
Little is known about the renal handling of oxalate in patients with idiopathic hypercalciuria (IH). To explore the role of tubular oxalate handling in IH and to evaluate whether differences exist between IH and normal controls, we studied 19 IH subjects, 8 normal subjects, and 2 bariatric stone formers (BSF) during a 1-day General Clinical Research Center protocol utilizing a low-oxalate diet. Urine and blood samples were collected at 30- to 60-min intervals while subjects were fasting and after they ate three meals providing known amounts of calcium, phosphorus, sodium, protein, oxalate, and calories. Plasma oxalate concentrations and oxalate-filtered loads were similar between patients (includes IH and BSF) and controls in both the fasting and fed states. Urinary oxalate excretion was significantly higher in patients vs. controls regardless of feeding state. Fractional excretion of oxalate (FEOx) was >1, suggesting tubular secretion of oxalate, in 6 of 19 IH and both BSF, compared with none of the controls (P < 0.00001). Adjusted for water extraction along the nephron, urine oxalate rose more rapidly among patients than normal subjects with increases in plasma oxalate. Our findings identify tubular secretion of oxalate as a key mediator of hyperoxaluria in calcium stone formers, potentially as a means of maintaining plasma oxalate in a tight range.
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