Trial reportThe Journal of clinical endocrinology and metabolism2011
Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.
Trial report in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04044118 (Calorie Restriction Intervention Induces Enterotype-associated BMI Loss in Nonobese Individuals), which is not on this map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Calorie Restriction Intervention Induces Enterotype-associated BMI Loss in Nonobese Individuals
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- The effects of hesperidin supplementation on insulin resistance and sensitivity in adults: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2025Pooled it
- Comparison of the impact of exercise training combined with dietary intervention vs. dietary intervention alone in patients with obesity and metabolic syndrome-a systematic review.Frontiers in nutrition · 2025Pooled it
- Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients · 2020Pooled it
- Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Pooled it
- Comprehensive lifestyle interventionWorld journal of gastroenterology · 2019Trial
- Plasma fatty acyl-carnitines during 8 weeks of overfeeding: relation to diet energy expenditure and body composition: the PROOF study.Metabolism: clinical and experimental · 2018Trial
- Aerobic exercise training conserves insulin sensitivity for 1 yr following weight loss in overweight women.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Trial
- Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity.Metabolism: clinical and experimental · 2012Trial
- Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.PloS one · 2012Trial
- Exercise-Activated mPFC Tri-Synaptic Pathway Ameliorates Depression-Like Behaviors in Mouse.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms.International journal of molecular sciences · 2024Review
- Evaluating variations in metabolic profiles during the dry period related to the time of hyperketonemia onset in dairy cows.PloS one · 2023Article
- A Sled Dog Model for Positive Health Effects of Weight Management and Exercise.American journal of biochemistry & biotechnology · 2023Article
- Predicting energy intake in adults who are dieting and exercising.International journal of obesity (2005) · 2022Article
- Secondary analysis of a university-based weight loss program in on-campus versus off-campus employees.Obesity science & practice · 2022Article
- Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.Osteoarthritis and cartilage open · 2020Article
- Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition.Annals of medicine · 2020Review
- Novel Markers of the Metabolic Impact of Exogenous Retinoic Acid with A Focus on Acylcarnitines and Amino Acids.International journal of molecular sciences · 2019Article
- Plasma Amino Acids During 8 Weeks of Overfeeding: Relation to Diet Body Composition and Fat Cell Size in the PROOF Study.Obesity (Silver Spring, Md.) · 2018Article
- Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesThe objective of the study was to evaluate whether serum concentrations of metabolic intermediates are related to adiposity and insulin sensitivity (Si) in overweight healthy subjects and compare changes in metabolic intermediates with similar weight loss achieved by diet only or diet plus exercise.
designThis was a randomized controlled trial. PARTICIPANTS AND
interventionThe cross-sectional study included 46 (aged 36.8 ± 1.0 yr) overweight (body mass index 27.8 ± 0.7 kg/m(2)) subjects enrolled in a 6-month study of calorie restriction. To determine the effect of diet only or diet plus exercise on metabolic intermediates, 35 subjects were randomized to control (energy intake at 100% of energy requirements); CR (25% calorie restriction), or CR+EX: (12.5% CR plus 12.5% increase in energy expenditure by exercise).
main outcome measuresSerum concentrations of eight fatty acids, 15 amino acids, and 45 acylcarnitines (ACs) measured by targeted mass spectrometry.
resultsIn overweight subjects, the concentrations of C2 AC and long-chain ACs were positively associated with percent fat (R(2) = 0.75, P = 0.0001) and Si (R(2) = 0.12, P = 0.05). The percent fat (R(2) = 0.77, P < 0.0001), abdominal visceral fat (R(2) = 0.64, P < 0.0001), and intrahepatic fat (R(2) = 0.30, P = 0.0002) were positively associated with fatty acid concentrations. There was a significant increase in an AC factor (comprised of C2 and several medium chain ACs) in the CR group (P = 0.01).
conclusionIn nonobese subjects, fasted serum ACs are associated with Si and fat mass. Despite similar weight loss, serum ACs increase with CR alone but not CR+EX. A greater improvement in Si with weight loss during CR+EX interventions may be related to improved coupling of β-oxidation and tricarboxylic acid cycle flux induced by exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.