Evidence map›Paper›PMID 21123040›Full record

ReviewCurrent opinion in immunology2011

Gaining a foothold: how HIV avoids innate immune recognition.

Nan Yan, Judy Lieberman

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Aicardi-Goutières syndrome: clues from the RNase H2 knock-out mouse.Journal of molecular medicine (Berlin, Germany) · 2013
    Review
  7. Article
  8. Liposomes as nanocarriers for anti-HIV therapy.Drug delivery and translational research · 2013
    Article
  9. Article
  10. Intrinsic antiviral immunity.Nature immunology · 2012
    Review
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nan YanImmune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States.
Judy Lieberman
Boston Children's Hospital · USHarvard University · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
TRANSFUSION BIOLOGY AND MEDICINET32HL066987 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI JOHN P MANIS · 2001 to 2026
$10.2M
Granzyme a Pathway of CTL-Mediated Cell DeathR01AI045587 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI LIEBERMAN, JUDY · 1999 to 2008
$4.4M
Granzyme A Pathway of CTL-Mediated Cell DeathR56AI045587 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI LIEBERMAN, JUDY · 2010 to 2010
$525k
NHLBI NIH HHS T32 HL066987NIAID NIH HHS AI045587NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI045587NIAID NIH HHS R56 AI045587
6 · The paper itself

Abstract

During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in infected CD4 T cells and macrophages by harnessing a host cytoplasmic DNase TREX1 to digest nonproductive HIV reverse transcripts.

Indexed as

Immunity, InnateAnimalsCD4-Positive T-LymphocytesHIV InfectionsHumansRNA, ViralRNA, Viral

Identifiers

PMID21123040
PMCPMC3042516
OpenAlexW2008219975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.