ArticleSchizophrenia research2011
Early and broadly defined psychosis risk mental states.
Article in Schizophrenia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02459210 (CLUES), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CLUES (Cognition for Learning and for Understanding Everyday Social Situations): An Adaptation of Cognitive Enhancement Therapy for Persons at Clinical High Risk for Psychosis
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis.Molecular psychiatry · 2024Pooled it
- Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies.Neuroscience and biobehavioral reviews · 2021Pooled it
- An integrated neurocognitive and social-cognitive treatment for youth at clinical high risk for psychosis: Cognition for Learning and for Understanding Everyday Social Situations (CLUES).Schizophrenia research · 2019Trial
- Co-existence of clinical high-risk for psychosis and bipolar disorder: a multi-dimensional psychopathological analysis.BMC psychiatry · 2026Article
- GABAMolecular psychiatry · 2026Article
- Enhancing Role Functioning in Clinical High Risk for Psychosis: An Open Trial of "InVEST" (Individualised Vocational and Educational Support and Training).Early intervention in psychiatry · 2025Article
- Macro- and Microstructural Alterations in the Midbrain in Early Psychosis Associates with Clinical Symptom Scores.eNeuro · 2025Article
- Attenuated mental symptoms in the general population: first data from the observational cross-sectional ATTENTION study in Greece.CNS spectrums · 2025Observational
- Effect of early intervention for early-stage psychotic disorders on suicidal behaviours - a systematic review protocol.Frontiers in psychiatry · 2024Article
- Implementing Technologies to Enhance Coordinated Specialty Care Framework: Implementation Outcomes From a Development and Usability Study.JMIR formative research · 2023Article
- Individualized vocational and educational support and training for youth at clinical high risk for psychosis.Early intervention in psychiatry · 2022Article
- Abnormal corneal nerve morphology and brain volume in patients with schizophrenia.Scientific reports · 2022Article
- Article
- Functional connectome organization predicts conversion to psychosis in clinical high-risk youth from the SHARP program.Molecular psychiatry · 2020Article
- Altered resting-state functional connectivity in young children at familial high risk for psychotic illness: A preliminary study.Schizophrenia research · 2020Article
- A brief questionnaire measure of multidimensional schizotypy predicts interview-rated symptoms and impairment.PloS one · 2020Article
- Screening nursing students to identify those at high risk of poor mental health: a cross-sectional survey.BMJ open · 2019Article
- Distinct Time-Course of Alterations of Groups I and II Metabotropic Glutamate Receptor and GABAergic Receptor Expression Along the Dorsoventral Hippocampal Axis in an Animal Model of Psychosis.Frontiers in behavioral neuroscience · 2019Article
- Auditory Event-Related Potentials in Antipsychotic-Free Subjects With Ultra-High-Risk State and First-Episode Psychosis.Frontiers in psychiatry · 2019Article
- The Temporal Experience of Pleasure Scale (TEPS): Measurement Invariance Across Gender in Chinese University Students.Frontiers in psychology · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Current definitions of the prodromal (or at-risk mental state) phase of schizophrenia include attenuated and/or transient psychotic symptoms as well as a combination of different risk indicators and a recent significant deterioration in global functioning. Data accumulated to date suggest rates of conversion to frank psychosis within two years in 25 to 40% of cases supporting the validity of these criteria. However, at this late phase of illness, functional deterioration is often already pronounced, highlighting the need for earlier identification. Moreover, negative symptoms and social impairments, cognitive deficits, other non-psychotic psychopathology and/or functional decline and non-specific biological indicators, often can be detected well before the at-risk mental state as currently defined; indicating that a broad characterization of an earlier stage may be possible. Identifying specific criteria to define this group of individuals, starting from the framework of familial high-risk, can help define a broader group of people, including earlier at-risk mental states, for future research. The hope is that this research will help facilitate intervention at earlier stages that may in turn minimize functional deterioration, and delay, attenuate or even prevent transition to psychosis. The disadvantages as well as the potential benefits of this approach are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.