ArticleNeuroImage2011
Effects of alcohol on brain responses to social signals of threat in humans.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05032105 (.An Open-label Clinical Trial Evaluating the ExAblate Model 4000 Type-1 Focused Ultrasound Unilateral Thalamotomy for Patients With Treatment-refractory Focal Onset Epilepsy and Comorbid Anxiety.), which is not on this map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
.An Open-label Clinical Trial Evaluating the ExAblate Model 4000 Type-1 Focused Ultrasound Unilateral Thalamotomy for Patients With Treatment-refractory Focal Onset Epilepsy and Comorbid Anxiety.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Stress and alcohol impact network states involved in emotional processing: relevance of comorbid AUD and psychiatric illnesses.Psychopharmacology · 2026Pooled it
- The multimodal neuroimaging signatures and gene expression profiles for adverse childhood experiences.BMC medicine · 2025Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli.Alcoholism, clinical and experimental research · 2022Trial
- Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study.Psychopharmacology · 2013Trial
- Subjective and neural responses to intravenous alcohol in young adults with light and heavy drinking patterns.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Alcohol dose effects on stress response to cued threat vary by threat intensity.Psychopharmacology · 2011Trial
- Decoding the serotonin-alcohol crosstalk: the role of central serotonergic dysregulation in alcohol use disorder.Pharmacological reports : PR · 2026Review
- Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers.Psychiatry research. Neuroimaging · 2026Article
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Directional associations between antisocial behavior and alcohol use disorder symptoms from adolescence through adulthood: A sibling comparison cross-lagged approach.Alcohol, clinical & experimental research · 2025Article
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Gut Microbiome-Liver-Brain axis in Alcohol Use Disorder. The role of gut dysbiosis and stress in alcohol-related cognitive impairment progression: possible therapeutic approaches.Neurobiology of stress · 2025Article
- Low-intensity transcranial focused ultrasound of the amygdala modulates neural activation during emotion processing.Frontiers in neuroimaging · 2025Article
- The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025Review
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- Which risk factors significantly influence the outcome of traumatic brain injured patients with alcohol use disorder?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk.Journal of the American College of Cardiology · 2023Article
- Early life stress and substance use disorders: The critical role of adolescent substance use.Pharmacology, biochemistry, and behavior · 2022Review
- Alcohol's Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder.Alcohol research : current reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Alcohol is a known exogenous modulator of negative affect (anxiety, tension) in both animals and humans. It has been proposed that the anxiolytic effects of alcohol are mediated via the amygdala, an area critical to fear perception and responding. However, little is known about the acute effects of alcohol on amygdala reactivity to threatening information in humans. We used functional magnetic resonance imaging and a validated task to probe amygdala responses to social signals of threat in 12 healthy, social drinkers after a double-blind crossover administration of alcohol or placebo. We found that alcohol significantly reduced amygdala reactivity to threat signals. The current findings fit well with the notion that alcohol may attenuate threat-based responding and provide a potential brain-based mechanism for the link between alcohol and anxiety and/or social threat perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.