ArticleJournal of Crohn's & colitis2010
Paneth's disease.
Article in Journal of Crohn's & colitis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 124 citations in OpenAlex.
- Tissue transcriptional programs stratify Crohn's disease by therapeutic response and clinical outcomes.Scientific reports · 2026Article
- Pathobiont-triggered induction of goblet cell response drives regional susceptibility to inflammatory bowel disease.The Journal of clinical investigation · 2026Article
- Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Effects of β-alanine on intestinal development and immune performance of weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation.International journal of molecular sciences · 2022Review
- IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.Nature communications · 2022Article
- Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease.Frontiers in pharmacology · 2022Review
- Fatty acid metabolism and acyl-CoA synthetases in theWorld journal of hepatology · 2021Review
- Antagonism of Adherent Invasive E. coli LF82 With Human α-defensin 5 in the Follicle-associated Epithelium of Patients With Ileal Crohn's Disease.Inflammatory bowel diseases · 2021Article
- Corrigendum: Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier.Frontiers in nutrition · 2021Article
- Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier.Frontiers in nutrition · 2021Review
- The roles and functions of Paneth cells in Crohn's disease: A critical review.Cell proliferation · 2021Review
- Gene Signatures of Early Response to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease.International journal of molecular sciences · 2020Article
- An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway.Journal of translational medicine · 2020Article
- The role of probiotics on the roadmap to a healthy microbiota: a symposium report.Gut microbiome (Cambridge, England) · 2020Review
- An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease.Frontiers in immunology · 2020Review
- Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation.Frontiers in physiology · 2020Review
- Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis.Frontiers in immunology · 2020Article
- Ustekinumab is effective in biological refractory Crohn's disease patients-regardless of approval study selection criteria.Intestinal research · 2019Article
- Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
- Expression of concern · 2022-01-24Civil Proceedings · Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Legal Reasons and/or Threats · · See also: https://doi.org/10.1093/ecco-jcc/jjab225 Journal was previously published by Elsevier until 2015.
- Commented on by
- Erratum issuedCorrection.2023
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In about 70% of patients Crohn's disease (CD) affects the small intestine. This disease location is stable over time and associated with a genetic background different from isolated colonic disease. A characteristic feature of small intestinal host defense is the presence of Paneth cells at the bottom of the crypts of Lieberkühn. These cells produce different broad spectrum antimicrobial peptides (AMPs) most abundantly the α-defensins HD-5 and -6 (DEFA5 und DEFA6). In small intestinal Crohn's disease both these PC products are specifically reduced. As a functional consequence, ileal extracts from Crohn's disease patients are compromised in clearing bacteria and enteroadherent E. coli colonize the mucosa. Mechanisms for defective antimicrobial Paneth cell function are complex and include an association with a NOD2 loss of function mutation, a disturbance of the Wnt pathway transcription factor TCF7L2 (also known as TCF4), the autophagy factor ATG16L1, the endosomal stress protein XBP1, the toll-like receptor TLR9, the calcium mediated potassium channel KCNN4 as well as mutations or inactivation of HD5. Thus we conclude that small intestinal Crohn's disease is most likely a complex disease of the Paneth cell: Paneth's disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.