ArticleJournal of nanobiotechnology2010
Nanobiotechnology applications of reconstituted high density lipoprotein.
Article in Journal of nanobiotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Foam fractionation studies of recombinant human apolipoprotein A-I.Biochimica et biophysica acta. Biomembranes · 2024Article
- Construction and application of artificial lipoproteins using adiposomes.Journal of lipid research · 2023Article
- Isolation of recombinant apolipoprotein E4 N-terminal domain by foam fractionation.Protein expression and purification · 2023Article
- Extracellular vesicles and lipoproteins - Smart messengers of blood cells in the circulation.Journal of extracellular biology · 2022Review
- Foam fractionation of a recombinant biosurfactant apolipoprotein.Journal of biotechnology · 2022Article
- Lutein nanodisks protect human retinal pigment epithelial cells from UV light-induced damage.Frontiers in nanotechnology · 2022Article
- Calcium-induced release of cytochrome c from cardiolipin nanodisks: Implications for apoptosis.Biochimica et biophysica acta. Biomembranes · 2021Article
- Reconstituted HDL as a therapeutic delivery device.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021Review
- Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- Dye binding assay reveals doxorubicin preference for DNA versus cardiolipin.Analytical biochemistry · 2020Article
- Article
- Calcium-induced transformation of cardiolipin nanodisks.Biochimica et biophysica acta. Biomembranes · 2019Article
- Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.Investigational new drugs · 2018Article
- Evaluation of cardiolipin nanodisks as lipid replacement therapy for Barth syndromeJournal of biomedical research · 2018Article
- Endothelial nitric oxide synthase oxygenase on lipid nanodiscs: A nano-assembly reflecting native-like function of eNOS.Biochemical and biophysical research communications · 2017Article
- Nutlin-3a Nanodisks Induce p53 Stabilization and Apoptosis in a Subset of Cultured Glioblastoma Cells.Journal of nanomedicine & nanotechnology · 2017Article
- A facile method for isolation of recombinant human apolipoprotein A-I from E. coli.Protein expression and purification · 2017Article
- Nanodiscs in Membrane Biochemistry and Biophysics.Chemical reviews · 2017Review
- Conformational Changes in High-Density Lipoprotein Nanoparticles Induced by High Payloads of Paramagnetic Lipids.ACS omega · 2016Article
- Wnt3a nanodisks promote ex vivo expansion of hematopoietic stem and progenitor cells.Journal of nanobiotechnology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
High-density lipoprotein (HDL) plays a fundamental role in the Reverse Cholesterol Transport pathway. Prior to maturation, nascent HDL exist as disk-shaped phospholipid bilayers whose perimeter is stabilized by amphipathic apolipoproteins. Methods have been developed to generate reconstituted (rHDL) in vitro and these particles have been used in a variety of novel ways. To differentiate between physiological HDL particles and non-natural rHDL that have been engineered to possess additional components/functions, the term nanodisk (ND) is used. In this review, various applications of ND technology are described, such as their use as miniature membranes for solubilization and characterization of integral membrane proteins in a native like conformation. In other work, ND harboring hydrophobic biomolecules/drugs have been generated and used as transport/delivery vehicles. In vitro and in vivo studies show that drug loaded ND are stable and possess potent biological activity. A third application of ND is their use as a platform for incorporation of amphiphilic chelators of contrast agents, such as gadolinium, used in magnetic resonance imaging. Thus, it is demonstrated that the basic building block of plasma HDL can be repurposed for alternate functions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.