Evidence map›Paper›PMID 21122061›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2010

Relationships of total adiponectin and molecular weight fractions of adiponectin with free testosterone in African men and premenopausal women.

Jie Cui, XiangDong Wu, Jocelyn Andrel, Bonita Falkner

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Adiposity distribution influences circulating adiponectin levels.Translational research : the journal of laboratory and clinical medicine · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jie CuiDepartment of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
XiangDong Wu
Jocelyn Andrel
Bonita Falkner
Thomas Jefferson University · US

Funding

INSULIN, ANDROGEN, AND RISK IN AFRICAN-AMERICAN WOMENR01HL051547 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI FALKNER, BONITA · 1993 to 2005
$1.6M
NHLBI NIH HHS HL051547NHLBI NIH HHS R01 HL051547
6 · The paper itself

Abstract

Adiponectin, a protein secreted by adipose tissue, has anti-inflammatory, antithrombogenic, and antidiabetogenic effects. Lower plasma adiponectin levels are present in diabetes, obesity, and the metabolic syndrome. Adiponectin levels are higher in women compared with men. The purpose of this study was to determine whether there is a relationship between total adiponectin, or the molecular weight fractions of adiponectin, and testosterone levels in African American men and premenopausal women. A sample (N=48) of men and premenopausal women was selected based on high and low serum-free testosterone level. All patients had data on blood pressure, metabolic risk factors, and sex hormone levels. Stored plasma samples were assayed for total adiponectin. Molecular weight fractions of adiponectin were separated by gel electrophoresis and quantified by Western blot. Data analysis compared adiponectin (total and fractions) levels with androgen status in both sexes. Among men with high testosterone levels, all fractions of adiponectin were significantly lower than those in men with low testosterone (P<.05). In women with high testosterone, total adiponectin (P=.02) and all fractions of molecular weight adiponectin (P<.05) were lower compared with those in women with low testosterone. Plasma adiponectin levels are lower in both men and premenopausal women with relatively higher testosterone levels.

Indexed as

Black or African AmericanAdiponectinAdultBlood PressureBody Mass IndexFemaleHumansMaleMolecular WeightPremenopauseRetrospective StudiesSex CharacteristicsTestosteroneAdiponectinTestosterone

Identifiers

PMID21122061
PMCPMC3065940
OpenAlexW2031758391

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.