ArticleJournal of clinical hypertension (Greenwich, Conn.)2010
Renewed interest in chlorthalidone: evidence from the Veterans Health Administration.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.The pharmacogenomics journal · 2014Pooled it
- Chronic renin inhibition lowers blood pressure and reduces upright muscle sympathetic nerve activity in hypertensive seniors.The Journal of physiology · 2013Trial
- Spironolactone prevents chlorthalidone-induced sympathetic activation and insulin resistance in hypertensive patients.Hypertension (Dallas, Tex. : 1979) · 2012Trial
- Long-term effects of chlorthalidone versus hydrochlorothiazide on electrocardiographic left ventricular hypertrophy in the multiple risk factor intervention trial.Hypertension (Dallas, Tex. : 1979) · 2011Trial
- Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter.Nature communications · 2025Article
- Prescription Trends of Thiazide Diuretics in a Canadian Primary Care Population From 2015 to 2021.CJC open · 2024Article
- Thiazide Diuretic Utilization Within the VA.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023Article
- Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function.JAMA network open · 2021Article
- ProjectFlow: a configurable workflow management application for point of care research.JAMIA open · 2021Article
- Comparative Effectiveness of Anticholinergic Agents for Lower Urinary Tract Symptoms.Journal of managed care & specialty pharmacy · 2018Article
- Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic.Current opinion in cardiology · 2015Review
- Trends in prevalent and incident opioid receipt: an observational study in Veterans Health Administration 2004-2012.Journal of general internal medicine · 2015Observational
- Drug therapy of apparent treatment-resistant hypertension: focus on mineralocorticoid receptor antagonists.Drugs · 2015Review
- Which thiazide to choose as add-on therapy for hypertension?Integrated blood pressure control · 2014Review
- The Antihypertensive Efficacy of Chlorthalidone and Telmisartan in Indian Hypertensive Patients who were Uncontrolled with Hydrochlorothiazide and Telmisartan Combination-A Prospective and an Open Label Study.Journal of clinical and diagnostic research : JCDR · 2013Article
- Regional differences in prescribing quality among elder veterans and the impact of rural residence.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2013Article
- Which diuretic is the preferred agent for treating essential hypertension: hydrochlorothiazide or chlorthalidone?Current cardiology reports · 2012Review
- The comparative effectiveness of hydrochlorothiazide and chlorthalidone in an observational cohort of veterans.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
- Should two-drug initial therapy for hypertension be recommended for all patients?Current hypertension reports · 2012Review
- Guidelines for use of diuretics: a view from a member of JNC 7.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiazide-type diuretics are recommended in national hypertension treatment guidelines, but these guidelines do not give preference to a specific thiazide. Recently, increased use of chlorthalidone has been advocated. The authors reviewed national outpatient prescription data from the Veterans Health Administration from 2003 to 2008 to describe the prescribing trends within the thiazide class, focusing on hydrochlorothiazide and chlorthalidone. Among total thiazide users, the proportion who received hydrochlorothiazide remained stable (95.6% in 2008), but the number of new users of hydrochlorothiazide decreased nearly 30% during this period. In contrast, the proportion of chlorthalidone use among total thiazide users more than doubled (1.1% in 2003 to 2.4% in 2008), and the number of new chlorthalidone users increased by more than 40%. At the time of initiation, chlorthalidone was more likely to be added to an existing antihypertensive regimen; one quarter (25.1%) of new hydrochlorothiazide starts were in patients not receiving concurrent antihypertensive medications, compared with only 12.1% for chlorthalidone (odds ratio, 0.44; 95% confidence interval, 0.42-0.46). Evaluation of national prescribing trends indicates that hydrochlorothiazide remains the most commonly prescribed thiazide, but there appears to be a shift toward more new users of chlorthalidone.
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Registered trials
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