ArticleThe Journal of clinical investigation1990
Cytokine regulation of antigen-driven immunoglobulin production in filarial parasite infections in humans.
Article in The Journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Trial
- The Influence of IgE on Cultured Human Mast Cells.Allergy, asthma & immunology research · 2013Article
- Immune response and inhibitory effect of ketotifen on the BALB/c and C3H/HeN mice infected with Echinostoma hortense.Parasitology research · 2007Article
- Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis.Genes and immunity · 2003Article
- Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa.Infection and immunity · 1998Article
- Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases.Clinical microbiology reviews · 1996Review
- Anti-interleukin-4 modulation of the Th2 polarized response to the parasitic nematode Brugia pahangi.Infection and immunity · 1996Article
- Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease.Clinical and experimental immunology · 1995Article
- Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.The Journal of clinical investigation · 1993Article
- Modulation of cellular and humoral immunity, and disease manifestation during onset of patency in Brugia pahangi-infected dogs.Immunology · 1993Article
- Cytokine patterns in the pathogenesis of human leishmaniasis.The Journal of clinical investigation · 1993Article
- Local expression of antiinflammatory cytokines in cancer.The Journal of clinical investigation · 1993Article
- Review
- IgG subclass-restricted immune responses to allergens.Springer seminars in immunopathology · 1990Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To define the immunoregulatory mechanisms underlying serum IgE levels found in patients with filariasis, we studied polyclonal IgE production by peripheral blood mononuclear cells (PBMC) from 15 patients with filarial infections, with a focus on the role of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in the generation and regulation of the response. Spontaneous in vitro IgE production was elevated in 10 of the 15 patients (836-6,464 pg/ml; normals, less than 500 pg/ml). Addition of filarial parasite antigen to PBMC cultures significantly stimulated polyclonal IgE production in an antigen dose-dependent manner in 10 of 12 patients tested (P less than 0.001). The essential role of IL-4 in the generation of this response was demonstrated when simultaneous addition of anti-IL-4 completely inhibited antigen-stimulated IgE production in all 10 patients studied. An inhibitory role of endogenously produced IFN-gamma was also indicated when the addition of anti-IFN-gamma to the cultures significantly augmented filarial antigen-stimulated IgE production by 33-1,238% in these same patients. Addition of 10-1,000 U/ml of recombinant human IFN-gamma to PBMC completely inhibited parasite antigen-induced IgE production. This study demonstrates that filarial antigen-stimulated IgE production in patients with filariasis is mediated by IL-4 and down regulated by IFN-gamma and suggests that the amount of IgE produced depends on the relative quantity of IL-4 and IFN-gamma generated by parasite-specific T cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.