ReviewInvertebrate neuroscience : IN2010
The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans.
Review in Invertebrate neuroscience : IN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- The dopaminergic system ofRoyal Society open science · 2025Review
- Article
- Serotonin and Dopamine Mimic Glucose-Induced Reinforcement inFrontiers in physiology · 2021Article
- Serotonin in Animal Cognition and Behavior.International journal of molecular sciences · 2020Review
- Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA inGenetics · 2019Article
- Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch.eLife · 2015Article
- Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans.Journal of lipid research · 2015Article
- Article
- Feeding motivation as a personality trait in Nile tilapia (Oreochromis niloticus): role of serotonergic neurotransmission.Fish physiology and biochemistry · 2014Article
- A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology.PLoS genetics · 2014Article
- Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans.PLoS genetics · 2013Article
- A C. elegans model to study human metabolic regulation.Nutrition & metabolism · 2013Article
- The belly rules the nose: feeding state-dependent modulation of peripheral chemosensory responses.Current opinion in neurobiology · 2013Review
- Eat to reproduce: a key role for the insulin signaling pathway in adult insects.Frontiers in physiology · 2013Article
- siRNAs Trigger Efficient Silencing of a Parasitism Gene in Plant Parasitic Root-Knot Nematodes.Genes · 2012Article
- Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuromodulators: an essential part of survival.Journal of neurogeneticsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review considers the factors involved in the regulation of feeding and metabolism in response to food deprivation using Caenorhabditis elegans as a model organism. Some of the sensory neurons and interneurons involved in food intake are described, together with an overview of pharyngeal pumping. A number of chemical transmitters control feeding in C. elegans including 5-hydroxytryptamine (5-HT, serotonin), acetylcholine, glutamate, dopamine, octopamine, and tyramine. The roles of these transmitters are modified by neuropeptides, including FMRFamide-like peptides (FLPs), neuropeptide-like protein (NLPs), and insulin-like peptides. The precise effects of many of these neuropeptides have yet to be elucidated but increasingly they are being shown to play a role in feeding and metabolism in C. elegans. The regulation of fat stores is complex and appears to involve the expression of a large number of genes, many with mammalian homologues, suggesting that fat regulatory signalling is conserved across phyla. Finally, a brief comparison is made between C. elegans and mammals where for both, despite their evolutionary distance, classical transmitters and neuropeptides have anorectic or orexigenic properties. Thus, there is a rationale to support the argument that an understanding of the molecular and genetic basis of feeding and fat regulation in C. elegans may contribute to efforts aimed at the identification of targets for the treatment of conditions associated with abnormal metabolism and obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.