ArticlePediatric nephrology (Berlin, Germany)2011
Clinical outcome and occurrence of uveitis in children with idiopathic tubulointerstitial nephritis.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.Journal of nephrology · 2023Pooled it
- Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.Orphanet journal of rare diseases · 2017Pooled it
- IL-10 polymorphisms +434T/C, +504G/T, and -2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population.PloS one · 2019Trial
- Prednisone in the treatment of tubulointerstitial nephritis in children.Pediatric nephrology (Berlin, Germany) · 2013Trial
- Viral tubulointerstitial nephritis in children: A narrative review with a focus on adenovirus.Pediatric nephrology (Berlin, Germany) · 2026Review
- Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on.Acta ophthalmologica · 2026Article
- Successful long-term treatment of tubulointerstitial nephritis and uveitis with mycophenolate.BMJ case reports · 2025Article
- An updated approach to the evaluation of the urinary sediment.Pediatric nephrology (Berlin, Germany) · 2025Review
- Tubulointerstitial nephritis in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2025Review
- A Comprehensive Review of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome.Biomedicines · 2025Review
- Renal Prognosis in Children With Tubulointerstitial Nephritis and Uveitis Syndrome.Kidney international reports · 2021Article
- Long-term outcome of biopsy-proven idiopathic tubulointersitial nephritis with or without uveitis in children-a nationwide follow-up study.Pediatric nephrology (Berlin, Germany) · 2021Article
- Long-term clinical characteristics and renal prognosis of children with tubulointerstitial nephritis and uveitis syndrome.Pediatric nephrology (Berlin, Germany) · 2021Observational
- Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: a cross-sectional web-based survey.BMJ open · 2021Article
- A rare case of tubulointerstitial nephritis and uveitis (TINU) syndrome: Answers.Pediatric nephrology (Berlin, Germany) · 2020Article
- Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways.Pediatric nephrology (Berlin, Germany) · 2020Review
- Acute tubulointerstitial nephritis in children- a retrospective case series in a UK tertiary paediatric centre.BMC nephrology · 2020Article
- Etiologic Spectrum and Follow-Up Results of Noninfectious Uveitis in Children: A Single Referral Center Experience.Archives of rheumatology · 2019Article
- The Invisible Threat of Non-steroidal Anti-inflammatory Drugs for Kidneys.Frontiers in pediatrics · 2019Article
- Acute tubulointerstitial nephritis and polyclonal hypergammaglobulinaemia: Which is the culprit?Clinics and practice · 2018Article
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute idiopathic tubulointerstitial nephritis (TIN) is considered a condition with a good long-term prognosis. However, there is evidence that some patients develop permanent renal impairment. The aim of this study was to evaluate the clinical characteristics of TIN at the time of diagnosis in children and determine whether the findings upon presentation predict renal outcome. The clinical data and biopsy findings from 26 children with idiopathic TIN admitted to four Finnish university hospitals were analyzed retrospectively. Twenty-five patients (96%) manifested renal insufficiency. After the mean follow-up time of 2.75 years (SD 2.5; 0.9-13.5), 4 patients (15%) had permanent renal insufficiency and 8 patients (31%) had persistent low-molecular weight proteinuria. Uveitis was found in 12 patients (46%). Four of these patients (33%) developed chronic uveitis. Our analysis showed that none of the laboratory or biopsy findings upon presentation prognosticated renal outcome. No correlation between renal disease and uveitis could be found either. The occurrence of uveitis among TIN patients was higher than previously reported. Uveitis may develop late and without recurrence of renal dysfunction. Therefore, follow-up by a pediatrician and by an ophthalmologist is warranted in children with acute TIN for at least 12 months from diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.