SynthesisRheumatology international2012
Candidate gene studies of fibromyalgia: a systematic review and meta-analysis.
Synthesis in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 12 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project.Rheumatology (Oxford, England) · 2022Pooled it
- Mirtazapine for fibromyalgia in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia.The Cochrane database of systematic reviews · 2018Pooled it
- Association between low bone mineral density and fibromyalgia: a meta-analysis.Clinical rheumatology · 2017Pooled it
- Oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Gabapentin for fibromyalgia pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Cannabinoids for fibromyalgia.The Cochrane database of systematic reviews · 2016Pooled it
- Antipsychotics for fibromyalgia in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Selective serotonin reuptake inhibitors for fibromyalgia syndrome.The Cochrane database of systematic reviews · 2015Pooled it
- Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis.Rheumatology international · 2015Pooled it
- Cognitive behavioural therapies for fibromyalgia.The Cochrane database of systematic reviews · 2013Pooled it
- [Etiology and pathophysiology of fibromyalgia syndrome].Schmerz (Berlin, Germany) · 2012Guideline
- Evaluating skin biopsy findings in fibromyalgia: a systematic review.Reumatologia · 2026Review
- Fibromyalgia: Understanding, Diagnosis and Modern Approaches to Treatment.Journal of clinical medicine · 2025Review
- Metformin and fibromyalgia pathophysiology: current insights and promising future therapeutic strategies.Molecular biology reports · 2024Review
- Association of the Serotonin and Kynurenine Pathways as Possible Therapeutic Targets to Modulate Pain in Patients with Fibromyalgia.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Serotonin Transporter (5-Hydroxytryptamine Transporter, SERT, SLC6A4) and Sodium-dependent Reuptake Inhibitors as Modulators of Pain Behaviors and Analgesic Responses.The journal of pain · 2024Review
- Association ofPain research & management · 2023Article
- Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast of homozygotes. We also performed a systematic review with available data of the candidate genes. A total of 21 separate comparisons were considered in this systematic review and meta-analysis. Seventeen candidate genes and over 35 different polymorphisms were identified in studies on fibromyalgia susceptibility. Meta-analysis of the 5-HTTLPR S/L allele and COMT val158Met failed to reveal any association with fibromyalgia. However, meta-analysis of the C allele, CC + CT genotype, and CC versus TT genotype of the 5-HT2A receptor 102T/C polymorphism showed significant association with fibromyalgia. The overall OR of the association between the C allele and fibromyalgia was 1.333 (95% CI = 1.053-1.688, P = 0.017). The ORs for the CC + CT genotype, and CC versus TT genotype showed the same pattern as that observed for the C allele (OR = 1.541, 95% CI = 1.032-2.303, P = 0.035; OR = 1.838, 95% CI = 1.151-2.936, P = 0.011). This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia. In contrast, no association was found between the 5-HTTLPR S/L allele, COMT val158Met, and susceptibility to fibromyalgia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.