SynthesisSleep2010
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis.
Synthesis in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 261 citations in OpenAlex.
- Circadian realignment and depressed mood: A systematic review.Sleep medicine reviews · 2025Pooled it
- Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action.BMC medicine · 2018Pooled it
- Safety, Tolerability and Efficacy of Drugs for Treating Behavioural Insomnia in Children with Attention-Deficit/Hyperactivity Disorder: A Systematic Review with Methodological Quality Assessment.Paediatric drugs · 2017Pooled it
- Low-dose exogenous melatonin plus evening dim light and time in bed scheduling advances circadian phase irrespective of measured or estimated dim light melatonin onset time: preliminary findings.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Trial
- Effects and clinical feasibility of a behavioral treatment for sleep problems in adult attention deficit hyperactivity disorder (ADHD): a pragmatic within-group pilot evaluation.BMC psychiatry · 2019Trial
- Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.PLoS medicine · 2018Trial
- Effects of environment light during sleep on autonomic functions of heart rate and breathing.Sleep & breathing = Schlaf & Atmung · 2014Trial
- A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes.Breast cancer research and treatment · 2014Trial
- Evaluation of sleep, puberty and mental health in children with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomnia.Psychopharmacology · 2011Trial
- Article
- Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews.Journal of clinical pharmacology · 2026Review
- Circadian dimensions in insomnia disorder: mechanistic evidence, candidate phenotypes, and a phenotype-stratified research framework.Frontiers in psychiatry · 2026Article
- The Pinealoprive Syndrome: Myth or Reality?Advances and technical standards in neurosurgery · 2026Review
- The association between dietary insulin index and load with depression, anxiety and stress in university students: a cross-sectional study.Scientific reports · 2025Article
- Case report on melatonin overdose: Cause and concern.Sleep medicine: X · 2024Article
- Emotional Dysregulation and Sleep Problems: A Transdiagnostic Approach in Youth.Clinics and practice · 2024Article
- Melatonin Use in Pediatrics: A Clinical Review on Indications, Multisystem Effects, and Toxicity.Children (Basel, Switzerland) · 2024Review
- A circadian clock regulates the blood-brain barrier across phylogeny.Vitamins and hormones · 2024Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo perform a meta-analysis of the efficacy and safety of exogenous melatonin in advancing sleep-wake rhythm in patients with delayed sleep phase disorder.
designMeta analysis of papers indexed for PubMed, Embase, and the abstracts of sleep and chronobiologic societies (1990-2009). PATIENTS: Individuals with delayed sleep phase disorder.
interventionsAdministration of melatonin. MEASUREMENTS AND
resultsA meta-analysis of data of randomized controlled trials involving individuals with delayed sleep phase disorder that were published in English, compared melatonin with placebo, and reported 1 or more of the following: endogenous melatonin onset, clock hour of sleep onset, wake-up time, sleep-onset latency, and total sleep time. The 5 trials including 91 adults and 4 trials including 226 children showed that melatonin treatment advanced mean endogenous melatonin onset by 1.18 hours (95% confidence interval [CI]: 0.89-1.48 h) and clock hour of sleep onset by 0.67 hours (95% CI: 0.45-0.89 h). Melatonin decreased sleep-onset latency by 23.27 minutes (95% CI: 4.83 -41.72 min). The wake-up time and total sleep time did not change significantly.
conclusionsMelatonin is effective in advancing sleep-wake rhythm and endogenous melatonin rhythm in delayed sleep phase disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.