ArticleHFSP journal2010
From genes to neural tube defects (NTDs): insights from multiscale computational modeling.
Article in HFSP journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Hinge point emergence in mammalian spinal neurulation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Inferring cellular forces from image stacks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Mechanocellular models of epithelial morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Neural tube closure: cellular, molecular and biomechanical mechanisms.Development (Cambridge, England) · 2017Review
- Wide and high resolution tension measurement using FRET in embryo.Scientific reports · 2016Article
- Non-straight cell edges are important to invasion and engulfment as demonstrated by cell mechanics model.Biomechanics and modeling in mechanobiology · 2016Article
- Colloquium: Mechanical formalisms for tissue dynamics.The European physical journal. E, Soft matter · 2015Article
- Practical aspects of the cellular force inference toolkit (CellFIT).Methods in cell biology · 2015Article
- Article
- Quantitative approaches to uncover physical mechanisms of tissue morphogenesis.Current opinion in biotechnology · 2013Review
- Multiscale computational models of complex biological systems.Annual review of biomedical engineering · 2013Review
- Computational models for mechanics of morphogenesis.Birth defects research. Part C, Embryo today : reviews · 2012Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morphogenetic movements, and the embryonic phenotypes they ultimately produce, are the consequence of a series of events that involve signaling pathways, cytoskeletal components, and cell- and tissue-level mechanical interactions. In order to better understand how these events work together in the context of amphibian neurulation, an existing multiscale computational model was augmented. Geometric data for this finite element-based mechanical model were obtained from 3D surface reconstructions of live axolotl embryos and serial sections of fixed specimens. Tissue mechanical properties were modeled using cell-based constitutive equations that include internal force generation and cell rearrangement, and equation parameters were adjusted manually to reflect biochemical changes including alterations in Shroom or the planar-cell-polarity pathway. The model indicates that neural tube defects can arise when convergent extension of the neural plate is reduced by as little as 20%, when it is eliminated on one side of the embryo, when neural ridge elevation is disrupted, when tension in the non-neural ectoderm is increased, or when the ectoderm thickness is increased. Where comparable conditions could be induced in Xenopus embryos, good agreement was found, an important step in model validation. The model reveals the neurulating embryo to be a finely tuned biomechanical system.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.