ArticleHeredity2011
Inbreeding reveals stronger net selection on Drosophila melanogaster males: implications for mutation load and the fitness of sexual females.
Article in Heredity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sex-specific inbreeding depression: A meta-analysis.Ecology letters · 2022Pooled it
- Meta-analytic evidence that sexual selection improves population fitness.Nature communications · 2019Pooled it
- Article
- Quantitative genetics of trauma induced mortality inbioRxiv : the preprint server for biology · 2025Article
- Fitness consequences of sex chromosome aneuploidy in Drosophila melanogaster.PLoS genetics · 2025Article
- Maternal Provisioning of Offspring With Defence Chemicals in a Facultatively Parthenogenetic Stick Insect.Ecology and evolution · 2025Article
- Sex-specific viability effects of mutations in Drosophila melanogaster.Evolution; international journal of organic evolution · 2024Article
- Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba.PLoS genetics · 2022Article
- An unbiased test reveals no enrichment of sexually antagonistic polymorphisms on the human X chromosome.Proceedings. Biological sciences · 2022Article
- Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantitative and population genetic insights.Genetics · 2021Article
- Selection in males purges the mutation load on female fitness.Evolution letters · 2021Article
- The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics.Evolution letters · 2020Article
- Recessive Z-linked lethals and the retention of haplotype diversity in a captive butterfly population.Heredity · 2020Article
- No evidence of positive assortative mating for genetic quality in fruit flies.Proceedings. Biological sciences · 2019Article
- Quantifying maladaptation during the evolution of sexual dimorphism.Proceedings. Biological sciences · 2019Article
- Winners have higher pre-copulatory mating success but losers have better post-copulatory outcomes.Proceedings. Biological sciences · 2019Article
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
- Sex-specific dominance reversal of genetic variation for fitness.PLoS biology · 2018Article
- Hierarchical Assessment of Mutation Properties inG3 (Bethesda, Md.) · 2018Article
- Cross-generational comparison of reproductive success in recently caught strains of Drosophila melanogaster.BMC evolutionary biology · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stronger selection on males has the potential to lower the deleterious mutation load of females, reducing the cost of sex. However, few studies have directly quantified the strength of selection for both sexes. As the magnitude of inbreeding depression (ID) is related to the strength of selection, we measured the cost of inbreeding for both males and females in a laboratory population of Drosophila melanogaster. Using a novel technique for inbreeding, we found significant ID for both juvenile viability and adult fitness in both sexes. The genetic variation responsible for this depression in fitness appeared to be recessive for adult fitness (h=0.11) and partially additive for juvenile viability (h=0.29). ID was identical across the sexes in terms of juvenile viability but was significantly more deleterious for males than females as adults, even though female X-chromosome homogamety should predispose them to a higher inbreeding load. We estimated the strength of selection on adult males to be 1.24 greater than on adult females, and this appears to be a consequence of selection arising from competition for mates. Combined with the generally positive intersexual genetic correlation for inbred lines, our results suggest that the mutation load of sexual females could be meaningfully reduced by stronger selection acting on males.
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